About Myotonin-protein kinase
Myotonin-protein kinase (DMPK) is a protein
from Homo sapiens identified by UniProt accession
Q09013, 629 residues long.
MolForge cross-references it against 0 known binders and
392 disease associations.
Target properties
| Protein name | Myotonin-protein kinase |
|---|
| UniProt accession | Q09013 |
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| Gene | DMPK |
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| Organism | Homo sapiens |
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| Length | 629 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Approved drugs hitting this target (10)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (392)
Diseases linked to this target (Open Targets).
- Steinert myotonic dystrophy · score 0.78
- myotonic dystrophy type 1 · score 0.78
- breast adenocarcinoma · score 0.24
- genetic disorder · score 0.19
- neurodegenerative disease · score 0.18
- myotonic dystrophy · score 0.15
- chronic obstructive pulmonary disease · score 0.13
- catecholaminergic polymorphic ventricular tachycardia 1 · score 0.13
- Noonan syndrome · score 0.12
- endometrial cancer · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q09013-F1 | alphafold | PREDICTED | 77.64 | — |
Amino-acid sequence (629 residues)
MSAEVRLRRL QQLVLDPGFL GLEPLLDLLL GVHQELGASE LAQDKYVADF LQWAEPIVVR LKEVRLQRDD FEILKVIGRG AFSEVAVVKM KQTGQVYAMK IMNKWDMLKR GEVSCFREER DVLVNGDRRW ITQLHFAFQD ENYLYLVMEY YVGGDLLTLL SKFGERIPAE MARFYLAEIV MAIDSVHRLG YVHRDIKPDN ILLDRCGHIR LADFGSCLKL RADGTVRSLV AVGTPDYLSP EILQAVGGGP GTGSYGPECD WWALGVFAYE MFYGQTPFYA DSTAETYGKI VHYKEHLSLP LVDEGVPEEA RDFIQRLLCP PETRLGRGGA GDFRTHPFFF GLDWDGLRDS VPPFTPDFEG ATDTCNFDLV EDGLTAMVSG GGETLSDIRE GAPLGVHLPF VGYSYSCMAL RDSEVPGPTP MELEAEQLLE PHVQAPSLEP SVSPQDETAE VAVPAAVPAA EAEAEVTLRE LQEALEEEVL TRQSLSREME AIRTDNQNFA SQLREAEARN RDLEAHVRQL QERMELLQAE GATAVTGVPS PRATDPPSHL DGPPAVAVGQ CPLVGPGPMH RRHLLLPARV PRPGLSEALS LLLFAVVLSR AAALGCIGLV AHAGQLTAVW RRPGAARAP
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