About Dystrophia myotonica WD repeat-containing protein
Dystrophia myotonica WD repeat-containing protein (DMWD) is a protein
from Homo sapiens identified by UniProt accession
Q09019, 674 residues long.
MolForge cross-references it against 0 known binders and
50 disease associations.
Target properties
| Protein name | Dystrophia myotonica WD repeat-containing protein |
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| UniProt accession | Q09019 |
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| Gene | DMWD |
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| Organism | Homo sapiens |
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| Length | 674 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (50)
Diseases linked to this target (Open Targets).
- body height · score 0.12
- platelet count · score 0.11
- chronic obstructive pulmonary disease · score 0.11
- coronary artery disease · score 0.10
- serum albumin measurement · score 0.10
- systolic blood pressure · score 0.09
- FEV/FVC ratio · score 0.09
- platelet-to-lymphocyte ratio · score 0.08
- asthma · score 0.07
- eosinophil count · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q09019-F1 | alphafold | PREDICTED | 67.23 | — |
Amino-acid sequence (674 residues)
MAAGGAEGGS GPGAAMGDCA EIKSQFRTRE GFYKLLPGDG AARRSGPASA QTPVPPQPPQ PPPGPASASG PGAAGPASSP PPAGPGPGPA LPAVRLSLVR LGEPDSAGAG EPPATPAGLG SGGDRVCFNL GRELYFYPGC CRRGSQRSID LNKPIDKRIY KGTQPTCHDF NQFTAATETI SLLVGFSAGQ VQYLDLIKKD TSKLFNEERL IDKTKVTYLK WLPESESLFL ASHASGHLYL YNVSHPCASA PPQYSLLKQG EGFSVYAAKS KAPRNPLAKW AVGEGPLNEF AFSPDGRHLA CVSQDGCLRV FHFDSMLLRG LMKSYFGGLL CVCWSPDGRY VVTGGEDDLV TVWSFTEGRV VARGHGHKSW VNAVAFDPYT TRAEEAATAA GADGERSGEE EEEEPEAAGT GSAGGAPLSP LPKAGSITYR FGSAGQDTQF CLWDLTEDVL YPHPPLARTR TLPGTPGTTP PAASSSRGGE PGPGPLPRSL SRSNSLPHPA GGGKAGGPGV AAEPGTPFSI GRFATLTLQE RRDRGAEKEH KRYHSLGNIS RGGSGGSGSG GEKPSGPVPR SRLDPAKVLG TALCPRIHEV PLLEPLVCKK IAQERLTVLL FLEDCIITAC QEGLICTWAR PGKAFTDEET EAQTGEGSWP RSPSKSVVEG ISSQPGNSPS GTVV
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