Histone-binding protein RBBP4 (RBBP4)

About Histone-binding protein RBBP4

Histone-binding protein RBBP4 (RBBP4) is a protein from Homo sapiens identified by UniProt accession Q09028, 425 residues long. MolForge cross-references it against 0 known binders and 194 disease associations.

Target properties

Protein name	Histone-binding protein RBBP4
UniProt accession	Q09028
Gene	RBBP4
Organism	Homo sapiens
Length	425 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (194)

Diseases linked to this target (Open Targets).

viral disease · score 0.46
cancer · score 0.38
melanoma · score 0.37
breast carcinoma · score 0.37
acute myeloid leukemia · score 0.30
breast adenocarcinoma · score 0.29
ovarian cancer · score 0.28
glioblastoma multiforme · score 0.27
lung adenocarcinoma · score 0.24
esophageal cancer · score 0.22

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q09028-F1	alphafold	PREDICTED	91.71	—

Amino-acid sequence (425 residues)

MADKEAAFDD AVEERVINEE YKIWKKNTPF LYDLVMTHAL EWPSLTAQWL PDVTRPEGKD FSIHRLVLGT HTSDEQNHLV IASVQLPNDD AQFDASHYDS EKGEFGGFGS VSGKIEIEIK INHEGEVNRA RYMPQNPCII ATKTPSSDVL VFDYTKHPSK PDPSGECNPD LRLRGHQKEG YGLSWNPNLS GHLLSASDDH TICLWDISAV PKEGKVVDAK TIFTGHTAVV EDVSWHLLHE SLFGSVADDQ KLMIWDTRSN NTSKPSHSVD AHTAEVNCLS FNPYSEFILA TGSADKTVAL WDLRNLKLKL HSFESHKDEI FQVQWSPHNE TILASSGTDR RLNVWDLSKI GEEQSPEDAE DGPPELLFIH GGHTAKISDF SWNPNEPWVI CSVSEDNIMQ VWQMAENIYN DEDPEGSVDP EGQGS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards