About Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase (MGAT3) is a protein
from Homo sapiens identified by UniProt accession
Q09327, 533 residues long.
MolForge cross-references it against 0 known binders and
98 disease associations.
Target properties
| Protein name | Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
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| UniProt accession | Q09327 |
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| Gene | MGAT3 |
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| Organism | Homo sapiens |
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| Length | 533 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (98)
Diseases linked to this target (Open Targets).
- serum IgG glycosylation measurement · score 0.31
- reticulocyte count · score 0.31
- leukocyte count · score 0.27
- reticulocyte measurement · score 0.25
- cognitive function measurement · score 0.23
- self reported educational attainment · score 0.22
- intelligence · score 0.20
- myeloid white cell count · score 0.19
- IgG fucosylation measurement · score 0.19
- IgG digalactosylation measurement · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q09327-F1 | alphafold | PREDICTED | 78.93 | — |
Amino-acid sequence (533 residues)
MKMRRYKLFL MFCMAGLCLI SFLHFFKTLS YVTFPRELAS LSPNLVSSFF WNNAPVTPQA SPEPGGPDLL RTPLYSHSPL LQPLPPSKAA EELHRVDLVL PEDTTEYFVR TKAGGVCFKP GTKMLERPPP GRPEEKPEGA NGSSARRPPR YLLSARERTG GRGARRKWVE CVCLPGWHGP SCGVPTVVQY SNLPTKERLV PREVPRRVIN AINVNHEFDL LDVRFHELGD VVDAFVVCES NFTAYGEPRP LKFREMLTNG TFEYIRHKVL YVFLDHFPPG GRQDGWIADD YLRTFLTQDG VSRLRNLRPD DVFIIDDADE IPARDGVLFL KLYDGWTEPF AFHMRKSLYG FFWKQPGTLE VVSGCTVDML QAVYGLDGIR LRRRQYYTMP NFRQYENRTG HILVQWSLGS PLHFAGWHCS WCFTPEGIYF KLVSAQNGDF PRWGDYEDKR DLNYIRGLIR TGGWFDGTQQ EYPPADPSEH MYAPKYLLKN YDRFHYLLDN PYQEPRSTAA GGWRHRGPEG RPPARGKLDE AEV
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