About Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A (MGAT5) is a protein
from Homo sapiens identified by UniProt accession
Q09328, 741 residues long.
MolForge cross-references it against 0 known binders and
139 disease associations.
Target properties
| Protein name | Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A |
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| UniProt accession | Q09328 |
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| Gene | MGAT5 |
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| Organism | Homo sapiens |
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| Length | 741 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (139)
Diseases linked to this target (Open Targets).
- alkaline phosphatase measurement · score 0.47
- N-glycan measurement · score 0.44
- aspartate aminotransferase measurement · score 0.42
- eosinophil count · score 0.40
- blood protein measurement · score 0.39
- schizophrenia · score 0.39
- COVID-19 · score 0.37
- systemic lupus erythematosus · score 0.33
- protein measurement · score 0.31
- ST2 protein measurement · score 0.31
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q09328-F1 | alphafold | PREDICTED | 83.39 | — |
Amino-acid sequence (741 residues)
MALFTPWKLS SQKLGFFLVT FGFIWGMMLL HFTIQQRTQP ESSSMLREQI LDLSKRYIKA LAEENRNVVD GPYAGVMTAY DLKKTLAVLL DNILQRIGKL ESKVDNLVVN GTGTNSTNST TAVPSLVALE KINVADIING AQEKCVLPPM DGYPHCEGKI KWMKDMWRSD PCYADYGVDG STCSFFIYLS EVENWCPHLP WRAKNPYEEA DHNSLAEIRT DFNILYSMMK KHEEFRWMRL RIRRMADAWI QAIKSLAEKQ NLEKRKRKKV LVHLGLLTKE SGFKIAETAF SGGPLGELVQ WSDLITSLYL LGHDIRISAS LAELKEIMKK VVGNRSGCPT VGDRIVELIY IDIVGLAQFK KTLGPSWVHY QCMLRVLDSF GTEPEFNHAN YAQSKGHKTP WGKWNLNPQQ FYTMFPHTPD NSFLGFVVEQ HLNSSDIHHI NEIKRQNQSL VYGKVDSFWK NKKIYLDIIH TYMEVHATVY GSSTKNIPSY VKNHGILSGR DLQFLLRETK LFVGLGFPYE GPAPLEAIAN GCAFLNPKFN PPKSSKNTDF FIGKPTLREL TSQHPYAEVF IGRPHVWTVD LNNQEEVEDA VKAILNQKIE PYMPYEFTCE GMLQRINAFI EKQDFCHGQV MWPPLSALQV KLAEPGQSCK QVCQESQLIC EPSFFQHLNK DKDMLKYKVT CQSSELAKDI LVPSFDPKNK HCVFQGDLLL FSCAGAHPRH QRVCPCRDFI KGQVALCKDC L
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