About Potassium voltage-gated channel subfamily A member 1
Potassium voltage-gated channel subfamily A member 1 (KCNA1) is a protein
from Homo sapiens identified by UniProt accession
Q09470, 495 residues long.
MolForge cross-references it against 0 known binders and
516 disease associations.
Target properties
| Protein name | Potassium voltage-gated channel subfamily A member 1 |
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| UniProt accession | Q09470 |
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| Gene | KCNA1 |
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| Organism | Homo sapiens |
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| Length | 495 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (516)
Diseases linked to this target (Open Targets).
- episodic ataxia type 1 · score 0.85
- multiple sclerosis · score 0.59
- Myasthenia gravis · score 0.57
- Myokymia · score 0.51
- hereditary episodic ataxia · score 0.51
- genetic disorder · score 0.49
- Isaacs syndrome · score 0.47
- Familial dyskinesia and facial myokymia · score 0.46
- small cell carcinoma · score 0.46
- Muscle weakness · score 0.46
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q09470-F1 | alphafold | PREDICTED | 78.16 | — |
Amino-acid sequence (495 residues)
MTVMSGENVD EASAAPGHPQ DGSYPRQADH DDHECCERVV INISGLRFET QLKTLAQFPN TLLGNPKKRM RYFDPLRNEY FFDRNRPSFD AILYYYQSGG RLRRPVNVPL DMFSEEIKFY ELGEEAMEKF REDEGFIKEE ERPLPEKEYQ RQVWLLFEYP ESSGPARVIA IVSVMVILIS IVIFCLETLP ELKDDKDFTG TVHRIDNTTV IYNSNIFTDP FFIVETLCII WFSFELVVRF FACPSKTDFF KNIMNFIDIV AIIPYFITLG TEIAEQEGNQ KGEQATSLAI LRVIRLVRVF RIFKLSRHSK GLQILGQTLK ASMRELGLLI FFLFIGVILF SSAVYFAEAE EAESHFSSIP DAFWWAVVSM TTVGYGDMYP VTIGGKIVGS LCAIAGVLTI ALPVPVIVSN FNYFYHRETE GEEQAQLLHV SSPNLASDSD LSRRSSSTMS KSEYMEIEED MNNSIAHYRQ VNIRTANCTT ANQNCVNKSK LLTDV
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