About Non-homologous end joining factor IFFO1
Non-homologous end joining factor IFFO1 (IFFO1) is a protein
from Homo sapiens identified by UniProt accession
Q0D2I5, 559 residues long.
MolForge cross-references it against 0 known binders and
28 disease associations.
Target properties
| Protein name | Non-homologous end joining factor IFFO1 |
|---|
| UniProt accession | Q0D2I5 |
|---|
| Gene | IFFO1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 559 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (28)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.31
- erythrocyte count · score 0.12
- triglyceride measurement · score 0.10
- Red cell distribution width · score 0.09
- high density lipoprotein cholesterol measurement · score 0.09
- reticulocyte count · score 0.06
- mean platelet volume · score 0.06
- blood protein measurement · score 0.06
- apolipoprotein A 1 measurement · score 0.06
- cystatin C measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q0D2I5-F1 | alphafold | PREDICTED | 66.03 | — |
Amino-acid sequence (559 residues)
MNPLFGPNLF LLQQEQQGLA GPLGDSLGGD HFAGGGDLPP APLSPAGPAA YSPPGPGPAP PAAMALRNDL GSNINVLKTL NLRFRCFLAK VHELERRNRL LEKQLQQALE EGKQGRRGLG RRDQAVQTGF VSPIRPLGLQ LGARPAAVCS PSARVLGSPA RSPAGPLAPS AASLSSSSTS TSTTYSSSAR FMPGTIWSFS HARRLGPGLE PTLVQGPGLS WVHPDGVGVQ IDTITPEIRA LYNVLAKVKR ERDEYKRRWE EEYTVRIQLQ DRVNELQEEA QEADACQEEL ALKVEQLKAE LVVFKGLMSN NLSELDTKIQ EKAMKVDMDI CRRIDITAKL CDVAQQRNCE DMIQMFQVPS MGGRKRERKA AVEEDTSLSE SEGPRQPDGD EEESTALSIN EEMQRMLNQL REYDFEDDCD SLTWEETEET LLLWEDFSGY AMAAAEAQGE QEDSLEKVIK DTESLFKTRE KEYQETIDQI ELELATAKND MNRHLHEYME MCSMKRGLDV QMETCRRLIT QSGDRKSPAF TAVPLSDPPP PPSEAEDSDR DVSSDSSMR
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