Magnesium transporter NIPA4 (NIPAL4)

About Magnesium transporter NIPA4

Magnesium transporter NIPA4 (NIPAL4) is a protein from Homo sapiens identified by UniProt accession Q0D2K0, 404 residues long. MolForge cross-references it against 0 known binders and 124 disease associations.

Target properties

Protein name	Magnesium transporter NIPA4
UniProt accession	Q0D2K0
Gene	NIPAL4
Organism	Homo sapiens
Length	404 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (124)

Diseases linked to this target (Open Targets).

lamellar ichthyosis · score 0.70
congenital non-bullous ichthyosiform erythroderma · score 0.69
autosomal recessive congenital ichthyosis · score 0.47
erythrokeratodermia variabilis · score 0.27
FEV/FVC ratio · score 0.23
genetic disorder · score 0.19
congenital reticular ichthyosiform erythroderma · score 0.18
forced expiratory volume · score 0.17
asthma · score 0.15
neutrophil count · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q0D2K0-F1	alphafold	PREDICTED	79.31	—

Amino-acid sequence (404 residues)

MELRVSNTSC ENGSLLHLYC SSQEVLCQIV NDLSPEVPSN ATFHSWQERI RQNYGFYIGL GLAFLSSFLI GSSVILKKKG LLRLVATGAT RAVDGGFGYL KDAMWWAGFL TMAAGEVANF GAYAFAPATV VTPLGALSVL ISAILSSYFL RESLNLLGKL GCVICVAGST VMVIHAPEEE KVTTIMEMAS KMKDTGFIVF AVLLLVSCLI LIFVIAPRYG QRNILIYIII CSVIGAFSVA AVKGLGITIK NFFQGLPVVR HPLPYILSLI LALSLSTQVN FLNRALDIFN TSLVFPIYYV FFTTVVVTSS IILFKEWYSM SAVDIAGTLS GFVTIILGVF MLHAFKDLDI SCASLPHMHK NPPPSPAPEP TVIRLEDKNV LVDNIELAST SSPEEKPKVF IIHS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards