About Kelch-like protein 30
Kelch-like protein 30 (KLHL30) is a protein
from Homo sapiens identified by UniProt accession
Q0D2K2, 578 residues long.
MolForge cross-references it against 0 known binders and
21 disease associations.
Target properties
| Protein name | Kelch-like protein 30 |
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| UniProt accession | Q0D2K2 |
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| Gene | KLHL30 |
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| Organism | Homo sapiens |
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| Length | 578 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (21)
Diseases linked to this target (Open Targets).
- creatinine measurement · score 0.19
- mean corpuscular volume · score 0.15
- mean corpuscular hemoglobin concentration · score 0.15
- urate measurement · score 0.15
- mean corpuscular hemoglobin · score 0.15
- Red cell distribution width · score 0.14
- hemoglobin measurement · score 0.13
- hematocrit · score 0.12
- serum iron measurement · score 0.09
- transferrin saturation measurement · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q0D2K2-F1 | alphafold | PREDICTED | 87.04 | — |
Amino-acid sequence (578 residues)
MVRNVDDLDF HLPSHAQDML DGLQRLRSQP KLADVTLLVG GRELPCHRGL LALSSPYFHA MFAGDFAESF SARVELRDVE PAVVGQLVDF VYTGRLTITQ GNVEALTRTA ARLHFPSVQK VCGRYLQQQL DAANCLGICE FGEQQGLLGV AAKAWAFLRE NFEAVAREDE FLQLPRERLV TCLAGDLLQV QPEQSRLEAL MRWVRHDPQA RAAHLPELLS LVHLDAVPRP CVQQLLASEP LIQESEACRA ALSQGHDGAP LALQQKLEEV LVVVGGQALE EEEAGEEPTP GLGNFAFYNS KAKRWMALPD FPDYHKWGFS LAALNNNIYV TGGSRGTKTD TWSTTQAWCF PLKEASWKPV APMLKPRTNH ASAALNGEIY VIGGTTLDVV EVESYDPYTD SWTPVSPALK YVSNFSAAGC RGRLYLVGSS ACKYNALALQ CYNPVTDAWS VIASPFLPKY LSSPRCAALH GELYLIGDNT KKVYVYDPGA NLWQKVQSQH SLHENGALVP LGDALYVTGG RWQGMEGDYH VEMEAYDTVR DTWTRHGALP RLWLYHGAST VFLDVSKWTQ PSGPTQEH
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