About TBC1 domain family member 8B
TBC1 domain family member 8B (TBC1D8B) is a protein
from Homo sapiens identified by UniProt accession
Q0IIM8, 1120 residues long.
MolForge cross-references it against 0 known binders and
16 disease associations.
Target properties
| Protein name | TBC1 domain family member 8B |
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| UniProt accession | Q0IIM8 |
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| Gene | TBC1D8B |
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| Organism | Homo sapiens |
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| Length | 1120 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (16)
Diseases linked to this target (Open Targets).
- familial idiopathic steroid-resistant nephrotic syndrome · score 0.66
- nephrotic syndrome · score 0.29
- neurodegenerative disease · score 0.16
- acute pancreatitis · score 0.05
- osteosarcoma · score 0.01
- focal segmental glomerulosclerosis · score 0.00
- neoplasm · score 0.00
- Kidney Oncocytoma · score 0.00
- melanoma · score 0.00
- Epileptic encephalopathy · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q0IIM8-F1 | alphafold | PREDICTED | 78.59 | — |
Amino-acid sequence (1120 residues)
MWLKPEEVLL KNALKLWLME RSNDYFVLQR RRGYGEEGGG GLTGLLVGTL DSVLDSTAKV APFRILHQTP DSQVYLSIAC GANREEITKH WDWLEQNIMK TLSVFDSNED ITNFVQGKIR GLIAEEGKHC FAKEDDPEKF REALLKFEKC FGLPEKEKLV TYYSCSYWKG RVPCQGWLYL STNFLSFYSF LLGSEIKLII SWDEVSKLEK TSNVILTESI HVCSQGENHY FSMFLHINQT YLLMEQLANY AIRRLFDKET FDNDPVLYNP LQITKRGLEN RAHSEQFNAF FRLPKGESLK EVHECFLWVP FSHFNTHGKM CISENYICFA SQDGNQCSVI IPLREVLAID KTNDSSKSVI ISIKGKTAFR FHEVKDFEQL VAKLRLRCGA ASTQYHDIST ELAISSESTE PSDNFEVQSL TSQRECSKTV NTEALMTVFH PQNLETLNSK MLKEKMKEQS WKILFAECGR GVSMFRTKKT RDLVVRGIPE TLRGELWMLF SGAVNDMATN PDYYTEVVEQ SLGTCNLATE EIERDLRRSL PEHPAFQSDT GISALRRVLT AYAYRNPKIG YCQAMNILTS VLLLYAKEEE AFWLLVAVCE RMLPDYFNRR IIGALVDQAV FEELIRDHLP QLTEHMTDMT FFSSVSLSWF LTLFISVLPI ESAVNVVDCF FYDGIKAILQ LGLAILDYNL DKLLTCKDDA EAVTALNRFF DNVTNKDSPL PSNVQQGSNV SDEKTSHTRV DITDLIRESN EKYGNIRYED IHSMRCRNRL YVIQTLEETT KQNVLRVVSQ DVKLSLQELD ELYVIFKKEL FLSCYWCLGC PVLKHHDPSL PYLEQYQIDC QQFRALYHLL SPWAHSANKD SLALWTFRLL DENSDCLINF KEFSSAIDIM YNGSFTEKLK LLFKLHIPPA YTEVKSKDAS KGDELSKEEL LYFSQLHVSK PANEKEAESA KHSPEKGKGK IDIQAYLSQW QDELFKKEEN IKDLPRMNQS QFIQFSKTLY NLFHEDPEEE SLYQAIAVVT SLLLRMEEVG RKLHSPTSSA KGFSGTVCGS GGPSEEKTGS HLEKDPCSFR EEPQWSFAFE QILASLLNEP ALVRFFEKPI DVKAKLENAR ISQLRSRTKM
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