PI-PLC X domain-containing protein 2 (PLCXD2)

About PI-PLC X domain-containing protein 2

PI-PLC X domain-containing protein 2 (PLCXD2) is a protein from Homo sapiens identified by UniProt accession Q0VAA5, 305 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.

Target properties

Protein name	PI-PLC X domain-containing protein 2
UniProt accession	Q0VAA5
Gene	PLCXD2
Organism	Homo sapiens
Length	305 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (28)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.37
diastolic blood pressure · score 0.27
lobe attachment · score 0.18
hemorrhoid · score 0.18
eyelid disease · score 0.18
lacrimal apparatus disease · score 0.18
atrial fibrillation · score 0.14
peak expiratory flow · score 0.04
atrial flutter · score 0.04
glucuronate measurement · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q0VAA5-F1	alphafold	PREDICTED	79.76	—

Amino-acid sequence (305 residues)

MLAVRKARRK LRMGTICSPN PSGTKTSSEV CNADWMASLP PHLHNLPLSN LAIPGSHDSF SYWVDEKSPV GPDQTQAIKR LARISLVKKL MKKWSVTQNL TFREQLEAGI RYFDLRVSSK PGDADQEIYF IHGLFGIKVW DGLMEIDSFL TQHPQEIIFL DFNHFYAMDE THHKCLVLRI QEAFGNKLCP ACSVESLTLR TLWEKNCQVL IFYHCPFYKQ YPFLWPGKKI PAPWANTTSV RKLILFLETT LSERASRGSF HVSQAILTPR VKTIARGLVG GLKNTLVHSN RWNSHGPSLL SQERS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards