About Apolipoprotein B receptor
Apolipoprotein B receptor (APOBR) is a protein
from Homo sapiens identified by UniProt accession
Q0VD83, 1097 residues long.
MolForge cross-references it against 0 known binders and
94 disease associations.
Target properties
| Protein name | Apolipoprotein B receptor |
|---|
| UniProt accession | Q0VD83 |
|---|
| Gene | APOBR |
|---|
| Organism | Homo sapiens |
|---|
| Length | 1097 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (94)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.35
- platelet count · score 0.33
- type 1 diabetes mellitus · score 0.31
- mean platelet volume · score 0.30
- platelet crit · score 0.29
- thyroid disease · score 0.24
- platelet component distribution width · score 0.23
- allergic rhinitis · score 0.23
- self reported educational attainment · score 0.19
- lung adenocarcinoma · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q0VD83-F1 | alphafold | PREDICTED | 40.98 | — |
Amino-acid sequence (1097 residues)
MDFLRLYLPG LHQALRGALD SLGTFVSYLL GDAVPTVERE AQAAEELGVV AVGKTGKIVE EEAQEDLEGL RGSQNEGAGR LRGPGDDRRH EVGSSAVEQT WGWGDGSSHG SQAERQDSGA GETAKAARCQ EPSAHLEARK KSKAGSGACQ DRSGQAQERQ ESHEQEVNRE ERLRSWEQEE EEEEVRAREP GMARGAESEW TWHGETEGKA GAVGPKAAGD NREMEQGVRE ADAGETEEPG AEGAGKGEEV VVVEKACEST RAWGTWGPGA EPEDWGILGR EEARTTPGRE EARAILDGEE ARTISGGEEA ETASGGEEAE TASGGEEAGT ASGGEEAGIA SGGEAGTASG GEEAGTASGG EEAGTASGGD EAWTTSGKEE ADLLGVRQTE YGAVPGERLL EATGKVWVLE EEGDEEREAE VSPFPKQPQV LGTERTEEAA ESQTAGREAV GGQEAGESFE GQVDLRGKEA EMRQDLGIRA DRARMEELVQ AEEAQEERGS SRDPVAELPS DGEAEGTADL EATPEARPEE ELTGEESEAA QTSCGLLGVE WGGLTHSVTK GQGPELMGGA QTPTKQPEER EAGEVELMGV LALSKEEQER SLEAGPRHAG SVKPEASEAF PGAWENRTRK DMERGNTQED AADGEQREEE ETAGGQTLAA EAEGDRESEL SEVPEAGGEG LTTQDAGCGT EEGEASVSEN QELDGSTGAD AGPCPSLGEA YARETEDEEA EADRTSRRGW RLQAVAVGLP DREDAQTGSV AAGIMGGDVV PHISAAGAGE ALEGVLGQGW DSKEKEEAAA GEHAGGQEFG LEGSAEEEVT GRGSQVEAFE SREGGPWGGR VEAEESAGAE DSCGLDPAGS QTARAEGMGA MVEAGGLLEK WTLLEEEAVG WQEREQREDS EGRCGDYHPE GEAPRLLDAE GLMVTGGRRA EAKETEPESL EHVRGQEEQP THQAPAEAAP ESVGEAETAE AMGSARGGAA NSWSEAPLPG SLLDVSVPRS RVHLSRSSSQ RRSRPSFRRT PAWEQQEEPP APNPPEEELS APEQRPLQLE EPLEPSPLRH DGTPVPARRR PLGHGFGLAH PGMMQELQAR LGRPKPQ
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