About Break repair meiotic recombinase recruitment factor 1
Break repair meiotic recombinase recruitment factor 1 (BRME1) is a protein
from Homo sapiens identified by UniProt accession
Q0VDD7, 668 residues long.
MolForge cross-references it against 0 known binders and
112 disease associations.
Target properties
| Protein name | Break repair meiotic recombinase recruitment factor 1 |
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| UniProt accession | Q0VDD7 |
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| Gene | BRME1 |
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| Organism | Homo sapiens |
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| Length | 668 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (112)
Diseases linked to this target (Open Targets).
- genetic disorder · score 0.12
- azoospermia · score 0.10
- partial chromosome Y deletion · score 0.09
- spermatogenic failures 50 · score 0.09
- spermatogenic failure 25 · score 0.08
- male infertility with teratozoospermia due to single gene mutation · score 0.08
- spermatogenic failure, X-linked, 2 · score 0.08
- isochromosomy Yp · score 0.08
- spermatogenic failure 73 · score 0.08
- spermatogenic failure 59 · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q0VDD7-F1 | alphafold | PREDICTED | 46.67 | — |
Amino-acid sequence (668 residues)
MTKRKKLRTS GEGLCPPKPL KNPRLGDFYG DPQSSMLGCL HHPEEPEGKL GPVPSTQQHG EEPGKAVSSS PDEETGSPCR LLRQPEKEPA PLPPSQNSFG RFVPQFAKSR KTVTRKEEMK DEDRGSGAFS LETIAESSAQ SPGCQLLVET LGVPLQEATE LGDPTQADSA RPEQSSQSPV QAVPGSGDSQ PDDPPDRGTG LSASQRASQD HLSEQGADDS KPETDRVPGD GGQKEHLPSI DSEGEKPDRG APQEGGAQRT AGAGLPGGPQ EEGDGVPCTP ASAPTSGPAP GLGPASWCLE PGSVAQGSPD PQQTPSRMGR EGEGTHSSLG CSSLGMVVIA DLSTDPTELE ERALEVAGPD GQASAISPAS PRRKAADGGH RRALPGCTSL TGETTGESGE AGQDGKPPGD VLVGPTASLA LAPGSGESMM GAGDSGHASP DTGPCVNQKQ EPGPAQEEAE LGGQNLERDL EGFRVSPQAS VVLEHREIAD DPLQEPGAQQ GIPDTTSELA GQRDHLPHSA DQGTWADSLA VELDFLLDSQ IQDALDASDF EAPPEQLFPS GNKPGPCWPG PSSHANGDPV AVAKAQPRTF VGIQASEASR MEDATNVVRG LIVELSNLNR LIMGTHRDLE AFKRLNYRKT KLGGKAPLPY PSKGPGNIPR GDPPWREL
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