Heat shock 70 kDa protein 14 (HSPA14)

About Heat shock 70 kDa protein 14

Heat shock 70 kDa protein 14 (HSPA14) is a protein from Homo sapiens identified by UniProt accession Q0VDF9, 509 residues long. MolForge cross-references it against 0 known binders and 40 disease associations.

Target properties

Protein name	Heat shock 70 kDa protein 14
UniProt accession	Q0VDF9
Gene	HSPA14
Organism	Homo sapiens
Length	509 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (40)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.50
lymphocyte count · score 0.19
breast adenocarcinoma · score 0.18
protein measurement · score 0.14
blood protein measurement · score 0.08
cortical thickness · score 0.06
neuroimaging measurement · score 0.06
hepatocellular carcinoma · score 0.06
brain measurement · score 0.06
cotinine glucuronidation measurement · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q0VDF9-F1	alphafold	PREDICTED	91.39	—

Amino-acid sequence (509 residues)

MAAIGVHLGC TSACVAVYKD GRAGVVANDA GDRVTPAVVA YSENEEIVGL AAKQSRIRNI SNTVMKVKQI LGRSSSDPQA QKYIAESKCL VIEKNGKLRY EIDTGEETKF VNPEDVARLI FSKMKETAHS VLGSDANDVV ITVPFDFGEK QKNALGEAAR AAGFNVLRLI HEPSAALLAY GIGQDSPTGK SNILVFKLGG TSLSLSVMEV NSGIYRVLST NTDDNIGGAH FTETLAQYLA SEFQRSFKHD VRGNARAMMK LTNSAEVAKH SLSTLGSANC FLDSLYEGQD FDCNVSRARF ELLCSPLFNK CIEAIRGLLD QNGFTADDIN KVVLCGGSSR IPKLQQLIKD LFPAVELLNS IPPDEVIPIG AAIEAGILIG KENLLVEDSL MIECSARDIL VKGVDESGAS RFTVLFPSGT PLPARRQHTL QAPGSISSVC LELYESDGKN SAKEETKFAQ VVLQDLDKKE NGLRDILAVL TMKRDGSLHV TCTDQETGKC EAISIEIAS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards