Secernin-3 (SCRN3)

About Secernin-3

Secernin-3 (SCRN3) is a protein from Homo sapiens identified by UniProt accession Q0VDG4, 424 residues long. MolForge cross-references it against 0 known binders and 89 disease associations.

Target properties

Protein name	Secernin-3
UniProt accession	Q0VDG4
Gene	SCRN3
Organism	Homo sapiens
Length	424 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (89)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
HbA1c measurement · score 0.25
hemoglobin A1 measurement · score 0.19
adolescent idiopathic scoliosis · score 0.13
vital capacity · score 0.12
grip strength measurement · score 0.11
body fat percentage · score 0.11
triglyceride measurement · score 0.11
early-onset non-syndromic cataract · score 0.10
unipolar depression · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q0VDG4-F1	alphafold	PREDICTED	91.85	—

Amino-acid sequence (424 residues)

MEPFSCDTFV ALPPATVDNR IIFGKNSDRL YDEVQEVVYF PAVVHDNLGE RLKCTYIEID QVPETYAVVL SRPAWLWGAE MGANEHGVCI GNEAVWGREE VCDEEALLGM DLVRLGLERA DTAEKALNVI VDLLEKYGQG GNCTEGRMVF SYHNSFLIAD RNEAWILETA GKYWAAEKVQ EGVRNISNQL SITTKIAREH PDMRNYAKRK GWWDGKKEFD FAAAYSYLDT AKMMTSSGRY CEGYKLLNKH KGNITFETMM EILRDKPSGI NMEGEFLTTA SMVSILPQDS SLPCIHFFTG TPDPERSVFK PFIFVPHISQ LLDTSSPTFE LEDLVKKKSH FKPDRRHPLY QKHQQALEVV NNNEEKAKIM LDNMRKLEKE LFREMESILQ NKHLDVEKIV NLFPQCTKDE IQIYQSNLSV KVSS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards