About Fanconi anemia core complex-associated protein 100
Fanconi anemia core complex-associated protein 100 (FAAP100) is a protein
from Homo sapiens identified by UniProt accession
Q0VG06, 881 residues long.
MolForge cross-references it against 0 known binders and
173 disease associations.
Target properties
| Protein name | Fanconi anemia core complex-associated protein 100 |
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| UniProt accession | Q0VG06 |
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| Gene | FAAP100 |
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| Organism | Homo sapiens |
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| Length | 881 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (173)
Diseases linked to this target (Open Targets).
- refractive error · score 0.25
- breast adenocarcinoma · score 0.18
- Red cell distribution width · score 0.10
- mean corpuscular volume · score 0.10
- erythrocyte count · score 0.10
- mean corpuscular hemoglobin concentration · score 0.09
- primary ovarian insufficiency · score 0.09
- mean corpuscular hemoglobin · score 0.08
- red blood cell density measurement · score 0.08
- mean reticulocyte volume · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q0VG06-F1 | alphafold | PREDICTED | 73.90 | — |
Amino-acid sequence (881 residues)
MAGAAPRVRY LAGFCCPLGG LAAGKPRVLC HEAEVFLSTG SELVYVYDQE GGLLTAAFRF PDQVWHLELL APRRLLYALC ARRGLYCLSL DHPGRSRSTS QDDRDSEDGD QPSPVIPVDP DACILPDAAL CAFTLLDSVL VTLVQGPARW KMQLFEQPCP GEDPRPGGQI GEVELSSYTP PAGVPGKPAA PHFLPVLCSV SPSGSRVPHD LLGGSGGFTL EDALFGLLFG ADATLLQSPV VLCGLPDGQL CCVILKALVT SRSAPGDPNA LVKILHHLEE PVIFIGALKT EPQAAEAAEN FLPDEDVHCD CLVAFGHHGR MLAIKASWDE SGKLVPELRE YCLPGPVLCA ACGGGGRVYH STPSDLCVVD LSRGSTPLGP EQPEEGPGGL PPMLCPASLN ICSVVSLSAS PRTHEGGTKL LALSAKGRLM TCSLDLDSEM PGPARMTTES AGQKIKELLS GIGNISERVS FLKKAVDQRN KALTSLNEAM NVSCALLSSG TGPRPISCTT STTWSRLQTQ DVLMATCVLE NSSSFSLDQG WTLCIQVLTS SCALDLDSAC SAITYTIPVD QLGPGARREV TLPLGPGENG GLDLPVTVSC TLFYSLREVV GGALAPSDSE DPFLDECPSD VLPEQEGVCL PLSRHTVDML QCLRFPGLAP PHTRAPSPLG PTRDPVATFL ETCREPGSQP AGPASLRAEY LPPSVASIKV SAELLRAALK DGHSGVPLCC ATLQWLLAEN AAVDVVRARA LSSIQGVAPD GANVHLIVRE VAMTDLCPAG PIQAVEIQVE SSSLADICRA HHAVVGRMQT MVTEQATQGS SAPDLRVQYL RQIHANHETL LREVQTLRDR LCTEDEASSC ATAQRLLQVY RQLRHPSLIL L
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