Mesoderm posterior protein 2 (MESP2)

About Mesoderm posterior protein 2

Mesoderm posterior protein 2 (MESP2) is a protein from Homo sapiens identified by UniProt accession Q0VG99, 397 residues long. MolForge cross-references it against 0 known binders and 94 disease associations.

Target properties

Protein name	Mesoderm posterior protein 2
UniProt accession	Q0VG99
Gene	MESP2
Organism	Homo sapiens
Length	397 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (94)

Diseases linked to this target (Open Targets).

autosomal recessive spondylocostal dysostosis · score 0.70
neurodegenerative disease · score 0.30
electrocardiography · score 0.23
reticulocyte count · score 0.21
genetic disorder · score 0.19
spondylocostal dysostosis · score 0.13
cervical rib syndrome · score 0.10
Scheuermann disease · score 0.09
posterior fusion of lumbosacral vertebrae-blepharoptosis syndrome · score 0.08
intraocular pressure measurement · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q0VG99-F1	alphafold	PREDICTED	54.17	—

Amino-acid sequence (397 residues)

MAQSPPPQSL LGHDHWIFAQ GWGWAGHWDS TSPASSSDSS GSCPCDGARG LPQPQPPSCS SRAAEAAATT PRRARTGPAG GQRQSASERE KLRMRTLARA LHELRRFLPP SLAPAGQSLT KIETLRLAIR YIGHLSAVLG LSEESLQCRR RQRGDAGSPW GCPLCPDRGP AEAQTQAEGQ GQGQGQGQGQ GQGQGQGQGQ GQGQGRRPGL VSAVLAEASW GSPSACPGAQ AAPERLGRGV HDTDPWATPP YCPKIQSPPY SSQGTTSDAS LWTPPQGCPW TQSSPEPRNP PVPWTAAPAT LELAAVYQGL SVSPEPCLSL GAPSLLPHPS CQRLQPQTPG RCWSHSAEVV PNSEDQGPGA AFQLSEASPP QSSGLRFSGC PELWQEDLEG ARLGIFY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards