About Ragulator complex protein LAMTOR4
Ragulator complex protein LAMTOR4 (LAMTOR4) is a protein
from Homo sapiens identified by UniProt accession
Q0VGL1, 99 residues long.
MolForge cross-references it against 0 known binders and
32 disease associations.
Target properties
| Protein name | Ragulator complex protein LAMTOR4 |
|---|
| UniProt accession | Q0VGL1 |
|---|
| Gene | LAMTOR4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 99 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (32)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.48
- head and neck squamous cell carcinoma · score 0.18
- autosomal recessive primary microcephaly · score 0.12
- age at menarche · score 0.10
- diet measurement · score 0.10
- glycogen storage disease due to glycogen branching enzyme deficiency · score 0.05
- familial hyperthyroidism due to mutations in TSH receptor · score 0.04
- familial gestational hyperthyroidism · score 0.04
- thyroid cancer, nonmedullary, 1 · score 0.04
- hypothyroidism due to TSH receptor mutations · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q0VGL1-F1 | alphafold | PREDICTED | 87.88 | — |
Amino-acid sequence (99 residues)
MTSALTQGLE RIPDQLGYLV LSEGAVLASS GDLENDEQAA SAISELVSTA CGFRLHRGMN VPFKRLSVVF GEHTLLVTVS GQRVFVVKRQ NRGREPIDV
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