About Nexilin
Nexilin (NEXN) is a protein
from Homo sapiens identified by UniProt accession
Q0ZGT2, 675 residues long.
MolForge cross-references it against 0 known binders and
219 disease associations.
Target properties
| Protein name | Nexilin |
|---|
| UniProt accession | Q0ZGT2 |
|---|
| Gene | NEXN |
|---|
| Organism | Homo sapiens |
|---|
| Length | 675 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (219)
Diseases linked to this target (Open Targets).
- dilated cardiomyopathy 1CC · score 0.74
- hypertrophic cardiomyopathy 20 · score 0.73
- hypertrophic cardiomyopathy · score 0.57
- Rare familial disorder with hypertrophic cardiomyopathy · score 0.55
- dilated cardiomyopathy · score 0.42
- familial isolated dilated cardiomyopathy · score 0.37
- left ventricular noncompaction · score 0.37
- FEV/FVC ratio · score 0.35
- cardiomyopathy · score 0.35
- Red cell distribution width · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q0ZGT2-F1 | alphafold | PREDICTED | 69.68 | — |
Amino-acid sequence (675 residues)
MNDISQKAEI LLSSSKPVPK TYVPKLGKGD VKDKFEAMQR AREERNQRRS RDEKQRRKEQ YIREREWNRR KQEIKEMLAS DDEEDVSSKV EKAYVPKLTG TVKGRFAEME KQRQEEQRKR TEEERKRRIE QDMLEKRKIQ RELAKRAEQI EDINNTGTES ASEEGDDSLL ITVVPVKSYK TSGKMKKNFE DLEKEREEKE RIKYEEDKRI RYEEQRPSLK EAKCLSLVMD DEIESEAKKE SLSPGKLKLT FEELERQRQE NRKKQAEEEA RKRLEEEKRA FEEARRQMVN EDEENQDTAK IFKGYRPGKL KLSFEEMERQ RREDEKRKAE EEARRRIEEE KKAFAEARRN MVVDDDSPEM YKTISQEFLT PGKLEINFEE LLKQKMEEEK RRTEEERKHK LEMEKQEFEQ LRQEMGEEEE ENETFGLSRE YEELIKLKRS GSIQAKNLKS KFEKIGQLSE KEIQKKIEEE RARRRAIDLE IKEREAENFH EEDDVDVRPA RKSEAPFTHK VNMKARFEQM AKAREEEEQR RIEEQKLLRM QFEQREIDAA LQKKREEEEE EEGSIMNGST AEDEEQTRSG APWFKKPLKN TSVVDSEPVR FTVKVTGEPK PEITWWFEGE ILQDGEDYQY IERGETYCLY LPETFPEDGG EYMCKAVNNK GSAASTCILT IESKN
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