About Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (MGAT2) is a protein
from Homo sapiens identified by UniProt accession
Q10469, 447 residues long.
MolForge cross-references it against 0 known binders and
37 disease associations.
Target properties
| Protein name | Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
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| UniProt accession | Q10469 |
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| Gene | MGAT2 |
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| Organism | Homo sapiens |
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| Length | 447 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (37)
Diseases linked to this target (Open Targets).
- MGAT2-congenital disorder of glycosylation · score 0.79
- COVID-19 · score 0.37
- congenital disorder of glycosylation type II · score 0.37
- Global developmental delay · score 0.26
- Abnormal facial shape · score 0.26
- genetic disorder · score 0.19
- congenital disorder of glycosylation · score 0.18
- blood protein measurement · score 0.10
- mathematical ability · score 0.07
- wellbeing measurement · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q10469-F1 | alphafold | PREDICTED | 84.95 | — |
Amino-acid sequence (447 residues)
MRFRIYKRKV LILTLVVAAC GFVLWSSNGR QRKNEALAPP LLDAEPARGA GGRGGDHPSV AVGIRRVSNV SAASLVPAVP QPEADNLTLR YRSLVYQLNF DQTLRNVDKA GTWAPRELVL VVQVHNRPEY LRLLLDSLRK AQGIDNVLVI FSHDFWSTEI NQLIAGVNFC PVLQVFFPFS IQLYPNEFPG SDPRDCPRDL PKNAALKLGC INAEYPDSFG HYREAKFSQT KHHWWWKLHF VWERVKILRD YAGLILFLEE DHYLAPDFYH VFKKMWKLKQ QECPECDVLS LGTYSASRSF YGMADKVDVK TWKSTEHNMG LALTRNAYQK LIECTDTFCT YDDYNWDWTL QYLTVSCLPK FWKVLVPQIP RIFHAGDCGM HHKKTCRPST QSAQIESLLN NNKQYMFPET LTISEKFTVV AISPPRKNGG WGDIRDHELC KSYRRLQ
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