About Polypeptide N-acetylgalactosaminyltransferase 1
Polypeptide N-acetylgalactosaminyltransferase 1 (GALNT1) is a protein
from Homo sapiens identified by UniProt accession
Q10472, 559 residues long.
MolForge cross-references it against 0 known binders and
65 disease associations.
Target properties
| Protein name | Polypeptide N-acetylgalactosaminyltransferase 1 |
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| UniProt accession | Q10472 |
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| Gene | GALNT1 |
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| Organism | Homo sapiens |
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| Length | 559 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (65)
Diseases linked to this target (Open Targets).
- severe acute respiratory syndrome · score 0.37
- COVID-19 · score 0.37
- heel bone mineral density · score 0.33
- sclerostin measurement · score 0.20
- appendicular lean mass · score 0.19
- monocyte count · score 0.16
- glioblastoma multiforme · score 0.13
- neoplasm · score 0.08
- hepatocellular carcinoma · score 0.08
- breast cancer · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q10472-F1 | alphafold | PREDICTED | 91.59 | — |
Amino-acid sequence (559 residues)
MRKFAYCKVV LATSLIWVLL DMFLLLYFSE CNKCDEKKER GLPAGDVLEP VQKPHEGPGE MGKPVVIPKE DQEKMKEMFK INQFNLMASE MIALNRSLPD VRLEGCKTKV YPDNLPTTSV VIVFHNEAWS TLLRTVHSVI NRSPRHMIEE IVLVDDASER DFLKRPLESY VKKLKVPVHV IRMEQRSGLI RARLKGAAVS KGQVITFLDA HCECTVGWLE PLLARIKHDR RTVVCPIIDV ISDDTFEYMA GSDMTYGGFN WKLNFRWYPV PQREMDRRKG DRTLPVRTPT MAGGLFSIDR DYFQEIGTYD AGMDIWGGEN LEISFRIWQC GGTLEIVTCS HVGHVFRKAT PYTFPGGTGQ IINKNNRRLA EVWMDEFKNF FYIISPGVTK VDYGDISSRV GLRHKLQCKP FSWYLENIYP DSQIPRHYFS LGEIRNVETN QCLDNMARKE NEKVGIFNCH GMGGNQVFSY TANKEIRTDD LCLDVSKLNG PVTMLKCHHL KGNQLWEYDP VKLTLQHVNS NQCLDKATEE DSQVPSIRDC NGSRSQQWLL RNVTLPEIF
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