D site-binding protein (DBP)

About D site-binding protein

D site-binding protein (DBP) is a protein from Homo sapiens identified by UniProt accession Q10586, 325 residues long. MolForge cross-references it against 0 known binders and 31 disease associations.

Target properties

Protein name	D site-binding protein
UniProt accession	Q10586
Gene	DBP
Organism	Homo sapiens
Length	325 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (31)

Diseases linked to this target (Open Targets).

lymphocyte percentage of leukocytes · score 0.16
neutrophil percentage of leukocytes · score 0.16
Red cell distribution width · score 0.15
lymphocyte count · score 0.10
neutrophil count · score 0.09
reticulocyte count · score 0.08
myeloid white cell count · score 0.08
reticulocyte measurement · score 0.07
leukocyte count · score 0.07
neutrophil-to-lymphocyte ratio · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q10586-F1	alphafold	PREDICTED	68.94	—

Amino-acid sequence (325 residues)

MARPVSDRTP APLLLGGPAG TPPGGGALLG LRSLLQGTSK PKEPASCLLK EKERKAALPA ATTPGPGLET AGPADAPAGA VVGGGSPRGR PGPVPAPGLL APLLWERTLP FGDVEYVDLD AFLLEHGLPP SPPPPGGPSP EPSPARTPAP SPGPGSCGSA SPRSSPGHAP ARAALGTASG HRAGLTSRDT PSPVDPDTVE VLMTFEPDPA DLALSSIPGH ETFDPRRHRF SEEELKPQPI MKKARKIQVP EEQKDEKYWS RRYKNNEAAK RSRDARRLKE NQISVRAAFL EKENALLRQE VVAVRQELSH YRAVLSRYQA QHGAL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards