About Mitochondrial-processing peptidase subunit alpha
Mitochondrial-processing peptidase subunit alpha (PMPCA) is a protein
from Homo sapiens identified by UniProt accession
Q10713, 525 residues long.
MolForge cross-references it against 0 known binders and
82 disease associations.
Target properties
| Protein name | Mitochondrial-processing peptidase subunit alpha |
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| UniProt accession | Q10713 |
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| Gene | PMPCA |
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| Organism | Homo sapiens |
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| Length | 525 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (82)
Diseases linked to this target (Open Targets).
- autosomal recessive spinocerebellar ataxia 2 · score 0.76
- Autosomal recessive cerebelloparenchymal disorder type 3 · score 0.73
- neurodegenerative disease · score 0.50
- Chronic lactic acidosis · score 0.42
- Global brain atrophy · score 0.42
- Failure to thrive · score 0.42
- Blindness · score 0.42
- normal pressure hydrocephalus · score 0.42
- hypertrophic cardiomyopathy · score 0.42
- Bilateral ptosis · score 0.42
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q10713-F1 | alphafold | PREDICTED | 88.27 | — |
Amino-acid sequence (525 residues)
MAAVVLAATR LLRGSGSWGC SRLRFGPPAY RRFSSGGAYP NIPLSSPLPG VPKPVFATVD GQEKFETKVT TLDNGLRVAS QNKFGQFCTV GILINSGSRY EAKYLSGIAH FLEKLAFSST ARFDSKDEIL LTLEKHGGIC DCQTSRDTTM YAVSADSKGL DTVVALLADV VLQPRLTDEE VEMTRMAVQF ELEDLNLRPD PEPLLTEMIH EAAYRENTVG LHRFCPTENV AKINREVLHS YLRNYYTPDR MVLAGVGVEH EHLVDCARKY LLGVQPAWGS AEAVDIDRSV AQYTGGIAKL ERDMSNVSLG PTPIPELTHI MVGLESCSFL EEDFIPFAVL NMMMGGGGSF SAGGPGKGMF SRLYLNVLNR HHWMYNATSY HHSYEDTGLL CIHASADPRQ VREMVEIITK EFILMGGTVD TVELERAKTQ LTSMLMMNLE SRPVIFEDVG RQVLATRSRK LPHELCTLIR NVKPEDVKRV ASKMLRGKPA VAALGDLTDL PTYEHIQTAL SSKDGRLPRT YRLFR
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