Galactoside alpha-(1,2)-fucosyltransferase 2 (FUT2)

About Galactoside alpha-(1,2)-fucosyltransferase 2

Galactoside alpha-(1,2)-fucosyltransferase 2 (FUT2) is a protein from Homo sapiens identified by UniProt accession Q10981, 343 residues long. MolForge cross-references it against 0 known binders and 276 disease associations.

Target properties

Protein name	Galactoside alpha-(1,2)-fucosyltransferase 2
UniProt accession	Q10981
Gene	FUT2
Organism	Homo sapiens
Length	343 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (276)

Diseases linked to this target (Open Targets).

alkaline phosphatase measurement · score 0.42
blood protein measurement · score 0.39
low density lipoprotein cholesterol measurement · score 0.38
vitamin B12 measurement · score 0.38
type 1 diabetes mellitus · score 0.37
breast milk measurement · score 0.37
total cholesterol measurement · score 0.36
Crohn's disease · score 0.36
cholelithiasis · score 0.34
cancer biomarker measurement · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q10981-F1	alphafold	PREDICTED	90.25	—

Amino-acid sequence (343 residues)

MLVVQMPFSF PMAHFILFVF TVSTIFHVQQ RLAKIQAMWE LPVQIPVLAS TSKALGPSQL RGMWTINAIG RLGNQMGEYA TLYALAKMNG RPAFIPAQMH STLAPIFRIT LPVLHSATAS RIPWQNYHLN DWMEEEYRHI PGEYVRFTGY PCSWTFYHHL RQEILQEFTL HDHVREEAQK FLRGLQVNGS RPGTFVGVHV RRGDYVHVMP KVWKGVVADR RYLQQALDWF RARYSSLIFV VTSNGMAWCR ENIDTSHGDV VFAGDGIEGS PAKDFALLTQ CNHTIMTIGT FGIWAAYLTG GDTIYLANYT LPDSPFLKIF KPEAAFLPEW TGIAADLSPL LKH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards