About 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5 (FUT5) is a protein
from Homo sapiens identified by UniProt accession
Q11128, 374 residues long.
MolForge cross-references it against 0 known binders and
34 disease associations.
Target properties
| Protein name | 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5 |
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| UniProt accession | Q11128 |
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| Gene | FUT5 |
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| Organism | Homo sapiens |
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| Length | 374 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (34)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- heart rate response to recovery post exercise · score 0.30
- blood protein measurement · score 0.26
- heart rate variability measurement · score 0.22
- monocyte percentage of leukocytes · score 0.10
- intrahepatic cholangiocarcinoma · score 0.07
- eosinophil percentage of leukocytes · score 0.05
- heel bone mineral density · score 0.05
- eosinophil count · score 0.05
- neoplasm · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q11128-F1 | alphafold | PREDICTED | 87.68 | — |
Amino-acid sequence (374 residues)
MDPLGPAKPQ WLWRRCLAGL LFQLLVAVCF FSYLRVSRDD ATGSPRPGLM AVEPVTGAPN GSRCQDSMAT PAHPTLLILL WTWPFNTPVA LPRCSEMVPG AADCNITADS SVYPQADAVI VHHWDIMYNP SANLPPPTRP QGQRWIWFSM ESPSNCRHLE ALDGYFNLTM SYRSDSDIFT PYGWLEPWSG QPAHPPLNLS AKTELVAWAV SNWKPDSARV RYYQSLQAHL KVDVYGRSHK PLPKGTMMET LSRYKFYLAF ENSLHPDYIT EKLWRNALEA WAVPVVLGPS RSNYERFLPP DAFIHVDDFQ SPKDLARYLQ ELDKDHARYL SYFHWRETLR PRSFSWALAF CKACWKLQQE SRYQTVRSIA AWFT
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