Secernin-1 (SCRN1)

About Secernin-1

Secernin-1 (SCRN1) is a protein from Homo sapiens identified by UniProt accession Q12765, 414 residues long. MolForge cross-references it against 0 known binders and 54 disease associations.

Target properties

Protein name	Secernin-1
UniProt accession	Q12765
Gene	SCRN1
Organism	Homo sapiens
Length	414 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (54)

Diseases linked to this target (Open Targets).

psoriasis · score 0.31
prostate carcinoma · score 0.14
Familial prostate cancer · score 0.14
prostate cancer · score 0.14
oral squamous cell carcinoma · score 0.07
neoplasm · score 0.07
Crigler-Najjar syndrome type 2 · score 0.03
tauopathy · score 0.03
Dravet syndrome · score 0.03
red-green color blindness · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q12765-F1	alphafold	PREDICTED	94.07	—

Amino-acid sequence (414 residues)

MAAAPPSYCF VAFPPRAKDG LVVFGKNSAR PRDEVQEVVY FSAADHEPES KVECTYISID QVPRTYAIMI SRPAWLWGAE MGANEHGVCI ANEAINTREP AAEIEALLGM DLVRLGLERG ETAKEALDVI VSLLEEHGQG GNYFEDANSC HSFQSAYLIV DRDEAWVLET IGKYWAAEKV TEGVRCICSQ LSLTTKMDAE HPELRSYAQS QGWWTGEGEF NFSEVFSPVE DHLDCGAGKD SLEKQEESIT VQTMMNTLRD KASGVCIDSE FFLTTASGVS VLPQNRSSPC IHYFTGTPDP SRSIFKPFIF VDDVKLVPKT QSPCFGDDDP AKKEPRFQEK PDRRHELYKA HEWARAIIES DQEQGRKLRS TMLELEKQGL EAMEEILTSS EPLDPAEVGD LFYDCVDTEI KFFK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards