About HMG domain-containing protein 3
HMG domain-containing protein 3 (HMGXB3) is a protein
from Homo sapiens identified by UniProt accession
Q12766, 1292 residues long.
MolForge cross-references it against 0 known binders and
29 disease associations.
Target properties
| Protein name | HMG domain-containing protein 3 |
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| UniProt accession | Q12766 |
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| Gene | HMGXB3 |
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| Organism | Homo sapiens |
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| Length | 1292 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (29)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.50
- aspartate aminotransferase measurement · score 0.25
- BMI-adjusted waist circumference · score 0.23
- mean corpuscular volume · score 0.22
- cystatin C measurement · score 0.19
- aspartate aminotransferase to alanine aminotransferase ratio · score 0.16
- heel bone mineral density · score 0.15
- total blood protein measurement · score 0.13
- monocyte percentage of leukocytes · score 0.13
- low density lipoprotein cholesterol measurement · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q12766-F1 | alphafold | PREDICTED | 63.30 | — |
Amino-acid sequence (1292 residues)
MDASYDGTEV TVVMEEIEEA YCYTSPGPPK KKKKYKIHGE KTKKPRSAYL LYYYDIYLKV QQELPHLPQS EINKKISESW RLLSVAERSY YLEKAKLEKE GLDPNSKLSA LTAVVPDIPG FRKILPRSDY IIIPKSSLQE DRSCPQLELC VAQNQMSPKG PPLVSNTAPE TVPSHAGMAE QCLAVEALAE EVGALTQSGA VQEIATSEIL SQDVLLEDAS LEVGESHQPY QTSLVIEETL VNGSPDLPTG SLAVPHPQVG ESVSVVTVMR DSSESSSSAP ATQFIMLPLP AYSVVENPTS IKLTTTYTRR GHGTCTSPGC SFTYVTRHKP PKCPTCGNFL GGKWIPKEKP AKVKVELASG VSSKGSVVKR NQQPVTTEQN SSKENASKLT LENSEAVSQL LNVAPPREVG EESEWEEVII SDAHVLVKEA PGNCGTAVTK TPVVKSGVQP EVTLGTTDND SPGADVPTPS EGTSTSSPLP APKKPTGADL LTPGSRAPEL KGRARGKPSL LAAARPMRAI LPAPVNVGRG SSMGLPRARQ AFSLSDKTPS VRTCGLKPST LKQLGQPIQQ PSGPGEVKLP SGPSNRTSQV KVVEVKPDMF PPYKYSCTVT LDLGLATSRG RGKCKNPSCS YVYTNRHKPR ICPSCGVNLA KDRTEKTTKA IEVSSPLPDV LNATEPLSTA QREIQRQSTL QLLRKVLQIP ENESELAEVF ALIHELNSSR LILSNVSEET VTIEQTSWSN YYESPSTQCL LCSSPLFKGG QNSLAGPQEC WLLTASRLQT VTAQVKMCLN PHCLALHSFI DIYTGLFNVG NKLLVSLDLL FAIRNQIKLG EDPRVSINVV LKSVQEQTEK TLTSEELSQL QELLCNGYWA FECLTVRDYN DMICGICGVA PKVEMAQRSE ENVLALKSVE FTWPEFLGSN EVNVEDFWAT METEVIEQVA FPASIPITKF DASVIAPFFP PLMRGAVVVN TEKDKNLDVQ PVPGSGSALV RLLQEGTCKL DEIGSYSEEK LQHLLRQCGI PFGAEDSKDQ LCFSLLALYE SVQNGARAIR PPRHFTGGKI YKVCPHQVVC GSKYLVRGES ARDHVDLLAS SRHWPPVYVV DMATSVALCA DLCYPELTNQ MWGRNQGCFS SPTEPPVSVS CPELLDQHYT VDMTETEHSI QHPVTKTATR RIVHAGLQPN PGDPSAGHHS LALCPELAPY ATILASIVDS KPNGVRQRPI AFDNATHYYL YNRLMDFLTS REIVNRQIHD IVQSCQPGEV VIRDTLYRLG VAQIKTETEE EGEEEEVAAV AE
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