About Forkhead box protein O1
Forkhead box protein O1 (FOXO1) is a protein
from Homo sapiens identified by UniProt accession
Q12778, 655 residues long.
MolForge cross-references it against 0 known binders and
812 disease associations.
Target properties
| Protein name | Forkhead box protein O1 |
|---|
| UniProt accession | Q12778 |
|---|
| Gene | FOXO1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 655 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (812)
Diseases linked to this target (Open Targets).
- monocyte count · score 0.51
- monocyte percentage of leukocytes · score 0.49
- eosinophil count · score 0.49
- mean corpuscular volume · score 0.48
- reticulocyte count · score 0.47
- platelet count · score 0.46
- heel bone mineral density · score 0.44
- mean corpuscular hemoglobin · score 0.44
- erythrocyte count · score 0.44
- Burkitts lymphoma · score 0.43
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q12778-F1 | alphafold | PREDICTED | 50.96 | — |
Amino-acid sequence (655 residues)
MAEAPQVVEI DPDFEPLPRP RSCTWPLPRP EFSQSNSATS SPAPSGSAAA NPDAAAGLPS ASAAAVSADF MSNLSLLEES EDFPQAPGSV AAAVAAAAAA AATGGLCGDF QGPEAGCLHP APPQPPPPGP LSQHPPVPPA AAGPLAGQPR KSSSSRRNAW GNLSYADLIT KAIESSAEKR LTLSQIYEWM VKSVPYFKDK GDSNSSAGWK NSIRHNLSLH SKFIRVQNEG TGKSSWWMLN PEGGKSGKSP RRRAASMDNN SKFAKSRSRA AKKKASLQSG QEGAGDSPGS QFSKWPASPG SHSNDDFDNW STFRPRTSSN ASTISGRLSP IMTEQDDLGE GDVHSMVYPP SAAKMASTLP SLSEISNPEN MENLLDNLNL LSSPTSLTVS TQSSPGTMMQ QTPCYSFAPP NTSLNSPSPN YQKYTYGQSS MSPLPQMPIQ TLQDNKSSYG GMSQYNCAPG LLKELLTSDS PPHNDIMTPV DPGVAQPNSR VLGQNVMMGP NSVMSTYGSQ ASHNKMMNPS SHTHPGHAQQ TSAVNGRPLP HTVSTMPHTS GMNRLTQVKT PVQVPLPHPM QMSALGGYSS VSSCNGYGRM GLLHQEKLPS DLDGMFIERL DCDMESIIRN DLMDGDTLDF NFDNVLPNQS FPHSVKTTTH SWVSG
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