About Transducin beta-like protein 3
Transducin beta-like protein 3 (TBL3) is a protein
from Homo sapiens identified by UniProt accession
Q12788, 808 residues long.
MolForge cross-references it against 0 known binders and
17 disease associations.
Target properties
| Protein name | Transducin beta-like protein 3 |
|---|
| UniProt accession | Q12788 |
|---|
| Gene | TBL3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 808 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (17)
Diseases linked to this target (Open Targets).
- cardiovascular disease · score 0.04
- hypertension · score 0.03
- mean platelet volume · score 0.03
- Huntington disease · score 0.01
- neoplasm · score 0.00
- infect · score 0.00
- infection · score 0.00
- acute myeloid leukemia · score 0.00
- type 2 diabetes mellitus · score 0.00
- Mobius syndrome · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q12788-F1 | alphafold | PREDICTED | 84.21 | — |
Amino-acid sequence (808 residues)
MAETAAGVGR FKTNYAVERK IEPFYKGGKA QLDQTGQHLF CVCGTRVNIL EVASGAVLRS LEQEDQEDIT AFDLSPDNEV LVTASRALLL AQWAWQEGSV TRLWKAIHTA PVATMAFDPT STLLATGGCD GAVRVWDIVR HYGTHHFRGS PGVVHLVAFH PDPTRLLLFS SATDAAIRVW SLQDRSCLAV LTAHYSAVTS LAFSADGHTM LSSGRDKICI IWDLQSCQAT RTVPVFESVE AAVLLPEEPV SQLGVKSPGL YFLTAGDQGT LRVWEAASGQ CVYTQAQPPG PGQELTHCTL AHTAGVVLTA TADHNLLLYE ARSLRLQKQF AGYSEEVLDV RFLGPEDSHV VVASNSPCLK VFELQTSACQ ILHGHTDIVL ALDVFRKGWL FASCAKDQSV RIWRMNKAGQ VMCVAQGSGH THSVGTVCCS RLKESFLVTG SQDCTVKLWP LPKALLSKNT APDNGPILLQ AQTTQRCHDK DINSVAIAPN DKLLATGSQD RTAKLWALPQ CQLLGVFSGH RRGLWCVQFS PMDQVLATAS ADGTIKLWAL QDFSCLKTFE GHDASVLKVA FVSRGTQLLS SGSDGLVKLW TIKNNECVRT LDAHEDKVWG LHCSRLDDHA LTGASDSRVI LWKDVTEAEQ AEEQARQEEQ VVRQQELDNL LHEKRYLRAL GLAISLDRPH TVLTVIQAIR RDPEACEKLE ATMLRLRRDQ KEALLRFCVT WNTNSRHCHE AQAVLGVLLR REAPEELLAY EGVRAALEAL LPYTERHFQR LSRTLQAAAF LDFLWHNMKL PVPAAAPTPW ETHKGALP
Explore Transducin beta-like protein 3 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets