About Twinfilin-1
Twinfilin-1 (TWF1) is a protein
from Homo sapiens identified by UniProt accession
Q12792, 350 residues long.
MolForge cross-references it against 0 known binders and
103 disease associations.
Target properties
| Protein name | Twinfilin-1 |
|---|
| UniProt accession | Q12792 |
|---|
| Gene | TWF1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 350 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (103)
Diseases linked to this target (Open Targets).
- lung adenocarcinoma · score 0.09
- neoplasm · score 0.09
- cancer · score 0.05
- hepatocellular carcinoma · score 0.04
- uncombable hair syndrome · score 0.04
- coronary artery disease · score 0.04
- Griscelli disease · score 0.04
- Griscelli syndrome type 3 · score 0.04
- Griscelli disease type 3 · score 0.04
- Griscelli disease type 1 · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q12792-F1 | alphafold | PREDICTED | 85.51 | — |
Amino-acid sequence (350 residues)
MSHQTGIQAS EDVKEIFARA RNGKYRLLKI SIENEQLVIG SYSQPSDSWD KDYDSFVLPL LEDKQPCYIL FRLDSQNAQG YEWIFIAWSP DHSHVRQKML YAATRATLKK EFGGGHIKDE VFGTVKEDVS LHGYKKYLLS QSSPAPLTAA EEELRQIKIN EVQTDVGVDT KHQTLQGVAF PISREAFQAL EKLNNRQLNY VQLEIDIKNE IIILANTTNT ELKDLPKRIP KDSARYHFFL YKHSHEGDYL ESIVFIYSMP GYTCSIRERM LYSSCKSRLL EIVERQLQMD VIRKIEIDNG DELTADFLYE EVHPKQHAHK QSFAKPKGPA GKRGIRRLIR GPAETEATTD
Explore Twinfilin-1 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets