Proline-rich nuclear receptor coactivator 1 (PNRC1)

About Proline-rich nuclear receptor coactivator 1

Proline-rich nuclear receptor coactivator 1 (PNRC1) is a protein from Homo sapiens identified by UniProt accession Q12796, 327 residues long. MolForge cross-references it against 0 known binders and 31 disease associations.

Target properties

Protein name	Proline-rich nuclear receptor coactivator 1
UniProt accession	Q12796
Gene	PNRC1
Organism	Homo sapiens
Length	327 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (31)

Diseases linked to this target (Open Targets).

body height · score 0.39
monocyte count · score 0.33
monocyte percentage of leukocytes · score 0.29
sleep duration · score 0.13
neutrophil percentage of leukocytes · score 0.10
mental or behavioural disorder · score 0.10
neoplasm · score 0.05
breast carcinoma · score 0.03
cancer · score 0.03
COVID-19 · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q12796-F1	alphafold	PREDICTED	58.22	—

Amino-acid sequence (327 residues)

MTVVSVPQRE PLVLGGRLAP LGFSSRGYFG ALPMVTTAPP PLPRIPDPRA LPPTLFLPHF LGGDGPCLTP QPRAPAALPN RSLAVAGGTP RAAPKKRRKK KVRASPAGQL PSRFHQYQQH RPSLEGGRSP ATGPSGAQEV PGPAAALAPS PAAAAGTEGA SPDLAPLRPA APGQTPLRKE VLKSKMGKSE KIALPHGQLV HGIHLYEQPK INRQKSKYNL PLTKITSAKR NENNFWQDSV SSDRIQKQEK KPFKNTENIK NSHLKKSAFL TEVSQKENYA GAKFSDPPSP SVLPKPPSHW MGSTVENSNQ NRELMAVHLK TLLKVQT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards