About Centrin-1
Centrin-1 (CETN1) is a protein
from Homo sapiens identified by UniProt accession
Q12798, 172 residues long.
MolForge cross-references it against 0 known binders and
130 disease associations.
Target properties
| Protein name | Centrin-1 |
|---|
| UniProt accession | Q12798 |
|---|
| Gene | CETN1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 172 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (130)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.32
- azoospermia · score 0.10
- male infertility with teratozoospermia due to single gene mutation · score 0.09
- blood protein measurement · score 0.08
- partial chromosome Y deletion · score 0.08
- spermatogenic failure 65 · score 0.07
- spermatogenic failure 56 · score 0.07
- spermatogenic failure, X-linked, 3 · score 0.07
- spermatogenic failure 72 · score 0.07
- spermatogenic failure 11 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q12798-F1 | alphafold | PREDICTED | 86.14 | — |
Amino-acid sequence (172 residues)
MASGFKKPSA ASTGQKRKVA PKPELTEDQK QEVREAFDLF DVDGSGTIDA KELKVAMRAL GFEPRKEEMK KMISEVDREG TGKISFNDFL AVMTQKMSEK DTKEEILKAF RLFDDDETGK ISFKNLKRVA NELGENLTDE ELQEMIDEAD RDGDGEVNEE EFLRIMKKTS LY
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