About Alpha-globin transcription factor CP2
Alpha-globin transcription factor CP2 (TFCP2) is a protein
from Homo sapiens identified by UniProt accession
Q12800, 502 residues long.
MolForge cross-references it against 0 known binders and
71 disease associations.
Target properties
| Protein name | Alpha-globin transcription factor CP2 |
|---|
| UniProt accession | Q12800 |
|---|
| Gene | TFCP2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 502 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (71)
Diseases linked to this target (Open Targets).
- leukocyte count · score 0.35
- mean corpuscular volume · score 0.11
- hepatocellular carcinoma · score 0.10
- myeloid white cell count · score 0.10
- melanoma · score 0.09
- neoplasm · score 0.07
- sarcoma · score 0.06
- drug use measurement · score 0.06
- mean corpuscular hemoglobin concentration · score 0.06
- esophageal squamous cell carcinoma · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q12800-F1 | alphafold | PREDICTED | 76.76 | — |
Amino-acid sequence (502 residues)
MAWALKLPLA DEVIESGLVQ DFDASLSGIG QELGAGAYSM SDVLALPIFK QEESSLPPDN ENKILPFQYV LCAATSPAVK LHDETLTYLN QGQSYEIRML DNRKLGELPE INGKLVKSIF RVVFHDRRLQ YTEHQQLEGW RWNRPGDRIL DIDIPMSVGI IDPRANPTQL NTVEFLWDPA KRTSVFIQVH CISTEFTMRK HGGEKGVPFR VQIDTFKENE NGEYTEHLHS ASCQIKVFKP KGADRKQKTD REKMEKRTPH EKEKYQPSYE TTILTECSPW PEITYVNNSP SPGFNSSHSS FSLGEGNGSP NHQPEPPPPV TDNLLPTTTP QEAQQWLHRN RFSTFTRLFT NFSGADLLKL TRDDVIQICG PADGIRLFNA LKGRMVRPRL TIYVCQESLQ LREQQQQQQQ QQQKHEDGDS NGTFFVYHAI YLEELTAVEL TEKIAQLFSI SPCQISQIYK QGPTGIHVLI SDEMIQNFQE EACFILDTMK AETNDSYHII LK
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