About EGF-containing fibulin-like extracellular matrix protein 1
EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1) is a protein
from Homo sapiens identified by UniProt accession
Q12805, 493 residues long.
MolForge cross-references it against 0 known binders and
404 disease associations.
Target properties
| Protein name | EGF-containing fibulin-like extracellular matrix protein 1 |
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| UniProt accession | Q12805 |
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| Gene | EFEMP1 |
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| Organism | Homo sapiens |
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| Length | 493 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (404)
Diseases linked to this target (Open Targets).
- Doyne honeycomb retinal dystrophy · score 0.60
- Inguinal hernia · score 0.58
- Familial drusen · score 0.56
- Myopia · score 0.51
- BMI-adjusted waist circumference · score 0.51
- body height · score 0.51
- lean body mass · score 0.50
- white matter hyperintensity measurement · score 0.49
- vital capacity · score 0.48
- forced expiratory volume · score 0.47
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q12805-F1 | alphafold | PREDICTED | 76.78 | — |
Amino-acid sequence (493 residues)
MLKALFLTML TLALVKSQDT EETITYTQCT DGYEWDPVRQ QCKDIDECDI VPDACKGGMK CVNHYGGYLC LPKTAQIIVN NEQPQQETQP AEGTSGATTG VVAASSMATS GVLPGGGFVA SAAAVAGPEM QTGRNNFVIR RNPADPQRIP SNPSHRIQCA AGYEQSEHNV CQDIDECTAG THNCRADQVC INLRGSFACQ CPPGYQKRGE QCVDIDECTI PPYCHQRCVN TPGSFYCQCS PGFQLAANNY TCVDINECDA SNQCAQQCYN ILGSFICQCN QGYELSSDRL NCEDIDECRT SSYLCQYQCV NEPGKFSCMC PQGYQVVRSR TCQDINECET TNECREDEMC WNYHGGFRCY PRNPCQDPYI LTPENRCVCP VSNAMCRELP QSIVYKYMSI RSDRSVPSDI FQIQATTIYA NTINTFRIKS GNENGEFYLR QTSPVSAMLV LVKSLSGPRE HIVDLEMLTV SSIGTFRTSS VLRLTIIVGP FSF
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