About Trophinin
Trophinin (TRO) is a protein
from Homo sapiens identified by UniProt accession
Q12816, 1431 residues long.
MolForge cross-references it against 0 known binders and
53 disease associations.
Target properties
| Protein name | Trophinin |
|---|
| UniProt accession | Q12816 |
|---|
| Gene | TRO |
|---|
| Organism | Homo sapiens |
|---|
| Length | 1431 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (53)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.15
- hepatocellular carcinoma · score 0.08
- experimental autoimmune encephalomyelitis · score 0.07
- neoplasm · score 0.05
- Infertility · score 0.02
- cancer · score 0.02
- ovarian carcinoma · score 0.02
- cholangiocarcinoma · score 0.01
- osteosarcoma · score 0.01
- calf circumference measurement · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q12816-F1 | alphafold | PREDICTED | 49.06 | — |
Amino-acid sequence (1431 residues)
MDRRNDYGYR VPLFQGPLPP PGSLGLPFPP DIQTETTEED SVLLMHTLLA ATKDSLAMDP PVVNRPKKSK TKKAPIKTIT KAAPAAPPVP AANEIATNKP KITWQALNLP VITQISQALP TTEVTNTQAS SVTAQPKKAN KMKRVTAKAA QGSQSPTGHE GGTIQLKSPL QVLKLPVISQ NIHAPIANES ASSQALITSI KPKKASKAKK AANKAIASAT EVSLAATATH TATTQGQITN ETASIHTTAA SIRTKKASKA RKTIAKVINT DTEHIEALNV TDAATRQIEA SVVAIRPKKS KGKKAASRGP NSVSEISEAP LATQIVTNQA LAATLRVKRG SRARKAATKA RATESQTPNA DQGAQAKIAS AQTNVSALET QVAAAVQALA DDYLAQLSLE PTTRTRGKRN RKSKHLNGDE RSGSNYRRIP WGRRPAPPRD VAILQERANK LVKYLLVKDQ TKIPIKRSDM LRDVIQEYDE YFPEIIERAS YTLEKMFRVN LKEIDKQSSL YILISTQESS AGILGTTKDT PKLGLLMVIL SVIFMNGNKA SEAVIWEVLR KLGLRPGVRH SLFGEVRKLI TDEFVKQKYL EYKRVPNSRP PEYEFFWGLR SYHETSKMKV LKFACRVQKK DPKDWAVQYR EAVEMEVQAA AVAVAEAEAR AEARAQMGIG EEAVAGPWNW DDMDIDCLTR EELGDDAQAW SRFSFEIEAR AQENADASTN VNFSRGASTR AGFSDGASIS FNGAPSSSGG FSGGPGITFG VAPSTSASFS NTASISFGGT LSTSSSFSSA ASISFGCAHS TSTSFSSEAS ISFGGMPCTS ASFSGGVSSS FSGPLSTSAT FSGGASSGFG GTLSTTAGFS GVLSTSTSFG SAPTTSTVFS SALSTSTGFG GILSTSVCFG GSPSSSGSFG GTLSTSICFG GSPCTSTGFG GTLSTSVSFG GSSSTSANFG GTLSTSICFD GSPSTGAGFG GALNTSASFG SVLNTSTGFG GAMSTSADFG GTLSTSVCFG GSPGTSVSFG SALNTNAGYG GAVSTNTDFG GTLSTSVCFG GSPSTSAGFG GALNTNASFG CAVSTSASFS GAVSTSACFS GAPITNPGFG GAFSTSAGFG GALSTAADFG GTPSNSIGFG AAPSTSVSFG GAHGTSLCFG GAPSTSLCFG SASNTNLCFG GPPSTSACFS GATSPSFCDG PSTSTGFSFG NGLSTNAGFG GGLNTSAGFG GGLGTSAGFS GGLSTSSGFD GGLGTSAGFG GGPGTSTGFG GGLGTSAGFS GGLGTSAGFG GGLVTSDGFG GGLGTNASFG STLGTSAGFS GGLSTSDGFG SRPNASFDRG LSTIIGFGSG SNTSTGFTGE PSTSTGFSSG PSSIVGFSGG PSTGVGFCSG PSTSGFSGGP STGAGFGGGP NTGAGFGGGP STSAGFGSGA ASLGACGFSY G
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