Ras-related protein Rab-40B (RAB40B)

About Ras-related protein Rab-40B

Ras-related protein Rab-40B (RAB40B) is a protein from Homo sapiens identified by UniProt accession Q12829, 278 residues long. MolForge cross-references it against 0 known binders and 58 disease associations.

Target properties

Protein name	Ras-related protein Rab-40B
UniProt accession	Q12829
Gene	RAB40B
Organism	Homo sapiens
Length	278 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (58)

Diseases linked to this target (Open Targets).

neoplasm · score 0.09
Blackfan-Diamond anemia · score 0.08
hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.08
hepatocellular carcinoma · score 0.07
alpha thalassemia-intellectual disability syndrome type 1 · score 0.07
Alpha-thalassemia - intellectual disability syndrome linked to chromosome 16 · score 0.07
delta-beta-thalassemia · score 0.06
hemoglobin D disease · score 0.06
hemoglobin E-beta-thalassemia syndrome · score 0.06
Alpha-thalassemia · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q12829-F1	alphafold	PREDICTED	75.71	—

Amino-acid sequence (278 residues)

MSALGSPVRA YDFLLKFLLV GDSDVGKGEI LASLQDGAAE SPYGHPAGID YKTTTILLDG RRVKLQLWDT SGQGRFCTIF RSYSRGAQGV ILVYDIANRW SFDGIDRWIK EIDEHAPGVP KILVGNRLHL AFKRQVPTEQ AQAYAERLGV TFFEVSPLCN FNITESFTEL ARIVLLRHGM DRLWRPSKVL SLQDLCCRAV VSCTPVHLVD KLPLPIALRS HLKSFSMANG LNARMMHGGS YSLTTSSTHK RSSLRKVKLV RPPQSPPKNC TRNSCKIS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards