Cell division cycle protein 20 homolog (CDC20)

About Cell division cycle protein 20 homolog

Cell division cycle protein 20 homolog (CDC20) is a protein from Homo sapiens identified by UniProt accession Q12834, 499 residues long. MolForge cross-references it against 0 known binders and 279 disease associations.

Target properties

Protein name	Cell division cycle protein 20 homolog
UniProt accession	Q12834
Gene	CDC20
Organism	Homo sapiens
Length	499 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (279)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
ovarian cancer · score 0.25
breast adenocarcinoma · score 0.25
lung adenocarcinoma · score 0.20
endometrial cancer · score 0.18
clear cell renal carcinoma · score 0.18
esophageal cancer · score 0.16
hepatocellular carcinoma · score 0.13
systolic blood pressure · score 0.12
neoplasm · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q12834-F1	alphafold	PREDICTED	84.12	—

Amino-acid sequence (499 residues)

MAQFAFESDL HSLLQLDAPI PNAPPARWQR KAKEAAGPAP SPMRAANRSH SAGRTPGRTP GKSSSKVQTT PSKPGGDRYI PHRSAAQMEV ASFLLSKENQ PENSQTPTKK EHQKAWALNL NGFDVEEAKI LRLSGKPQNA PEGYQNRLKV LYSQKATPGS SRKTCRYIPS LPDRILDAPE IRNDYYLNLV DWSSGNVLAV ALDNSVYLWS ASSGDILQLL QMEQPGEYIS SVAWIKEGNY LAVGTSSAEV QLWDVQQQKR LRNMTSHSAR VGSLSWNSYI LSSGSRSGHI HHHDVRVAEH HVATLSGHSQ EVCGLRWAPD GRHLASGGND NLVNVWPSAP GEGGWVPLQT FTQHQGAVKA VAWCPWQSNV LATGGGTSDR HIRIWNVCSG ACLSAVDAHS QVCSILWSPH YKELISGHGF AQNQLVIWKY PTMAKVAELK GHTSRVLSLT MSPDGATVAS AAADETLRLW RCFELDPARR REREKASAAK SSLIHQGIR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards