About Zona pellucida sperm-binding protein 4
Zona pellucida sperm-binding protein 4 (ZP4) is a protein
from Homo sapiens identified by UniProt accession
Q12836, 540 residues long.
MolForge cross-references it against 0 known binders and
46 disease associations.
Target properties
| Protein name | Zona pellucida sperm-binding protein 4 |
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| UniProt accession | Q12836 |
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| Gene | ZP4 |
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| Organism | Homo sapiens |
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| Length | 540 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (46)
Diseases linked to this target (Open Targets).
- cutaneous melanoma · score 0.25
- lung adenocarcinoma · score 0.25
- squamous cell lung carcinoma · score 0.18
- breast adenocarcinoma · score 0.16
- glioblastoma multiforme · score 0.15
- risk-taking behaviour · score 0.13
- head and neck squamous cell carcinoma · score 0.13
- white matter microstructure measurement · score 0.12
- prostate carcinoma · score 0.11
- prostate cancer · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q12836-F1 | alphafold | PREDICTED | 74.65 | — |
Amino-acid sequence (540 residues)
MWLLRCVLLC VSLSLAVSGQ HKPEAPDYSS VLHCGPWSFQ FAVNLNQEAT SPPVLIAWDN QGLLHELQND SDCGTWIRKG PGSSVVLEAT YSSCYVTEWD SHYIMPVGVE GAGAAEHKVV TERKLLKCPM DLLARDAPDT DWCDSIPARD RLPCAPSPIS RGDCEGLGCC YSSEEVNSCY YGNTVTLHCT REGHFSIAVS RNVTSPPLLL DSVRLALRND SACNPVMATQ AFVLFQFPFT SCGTTRQITG DRAVYENELV ATRDVKNGSR GSVTRDSIFR LHVSCSYSVS SNSLPINVQV FTLPPPFPET QPGPLTLELQ IAKDKNYGSY YGVGDYPVVK LLRDPIYVEV SILHRTDPYL GLLLQQCWAT PSTDPLSQPQ WPILVKGCPY IGDNYQTQLI PVQKALDLPF PSHHQRFSIF TFSFVNPTVE KQALRGPVHL HCSVSVCQPA ETPSCVVTCP DLSRRRNFDN SSQNTTASVS SKGPMILLQA TKDPPEKLRV PVDSKVLWVA GLSGTLILGA LLVSYLAVKK QKSCPDQMCQ
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