POU domain, class 4, transcription factor 2 (POU4F2)

About POU domain, class 4, transcription factor 2

POU domain, class 4, transcription factor 2 (POU4F2) is a protein from Homo sapiens identified by UniProt accession Q12837, 409 residues long. MolForge cross-references it against 0 known binders and 176 disease associations.

Target properties

Protein name	POU domain, class 4, transcription factor 2
UniProt accession	Q12837
Gene	POU4F2
Organism	Homo sapiens
Length	409 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (176)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.48
breast adenocarcinoma · score 0.25
glioblastoma multiforme · score 0.25
lung adenocarcinoma · score 0.19
esophageal cancer · score 0.18
squamous cell lung carcinoma · score 0.18
gastric adenocarcinoma · score 0.18
urinary bladder cancer · score 0.18
head and neck squamous cell carcinoma · score 0.18
endometrial cancer · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q12837-F1	alphafold	PREDICTED	61.79	—

Amino-acid sequence (409 residues)

MMMMSLNSKQ AFSMPHGGSL HVEPKYSALH STSPGSSAPI APSASSPSSS SNAGGGGGGG GGGGGGGGRS SSSSSSGSSG GGGSEAMRRA CLPTPPSNIF GGLDESLLAR AEALAAVDIV SQSKSHHHHP PHHSPFKPDA TYHTMNTIPC TSAASSSSVP ISHPSALAGT HHHHHHHHHH HHQPHQALEG ELLEHLSPGL ALGAMAGPDG AVVSTPAHAP HMATMNPMHQ AALSMAHAHG LPSHMGCMSD VDADPRDLEA FAERFKQRRI KLGVTQADVG SALANLKIPG VGSLSQSTIC RFESLTLSHN NMIALKPILQ AWLEEAEKSH REKLTKPELF NGAEKKRKRT SIAAPEKRSL EAYFAIQPRP SSEKIAAIAE KLDLKKNVVR VWFCNQRQKQ KRMKYSAGI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards