G-rich sequence factor 1 (GRSF1)

About G-rich sequence factor 1

G-rich sequence factor 1 (GRSF1) is a protein from Homo sapiens identified by UniProt accession Q12849, 480 residues long. MolForge cross-references it against 0 known binders and 46 disease associations.

Target properties

Protein name	G-rich sequence factor 1
UniProt accession	Q12849
Gene	GRSF1
Organism	Homo sapiens
Length	480 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (46)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.51
influenza · score 0.37
clear cell renal carcinoma · score 0.27
mean reticulocyte volume · score 0.19
mean corpuscular volume · score 0.19
Red cell distribution width · score 0.17
mean corpuscular hemoglobin concentration · score 0.16
type 2 diabetes mellitus · score 0.08
lung adenocarcinoma · score 0.07
hepatocellular carcinoma · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q12849-F1	alphafold	PREDICTED	65.54	—

Amino-acid sequence (480 residues)

MAGTRWVLGA LLRGCGCNCS SCRRTGAACL PFYSAAGSIP SGVSGRRRLL LLLGAAAAAA SQTRGLQTGP VPPGRLAGPP AVATSAAAAA AASYSALRAS LLPQSLAAAA AVPTRSYSQE SKTTYLEDLP PPPEYELAPS KLEEEVDDVF LIRAQGLPWS CTMEDVLNFF SDCRIRNGEN GIHFLLNRDG KRRGDALIEM ESEQDVQKAL EKHRMYMGQR YVEVYEINNE DVDALMKSLQ VKSSPVVNDG VVRLRGLPYS CNEKDIVDFF AGLNIVDITF VMDYRGRRKT GEAYVQFEEP EMANQALLKH REEIGNRYIE IFPSRRNEVR THVGSYKGKK IASFPTAKYI TEPEMVFEEH EVNEDIQPMT AFESEKEIEL PKEVPEKLPE AADFGTTSSL HFVHMRGLPF QANAQDIINF FAPLKPVRIT MEYSSSGKAT GEADVHFETH EDAVAAMLKD RSHVHHRYIE LFLNSCPKGK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards