Nuclear factor 1 A-type (NFIA)

About Nuclear factor 1 A-type

Nuclear factor 1 A-type (NFIA) is a protein from Homo sapiens identified by UniProt accession Q12857, 509 residues long. MolForge cross-references it against 0 known binders and 297 disease associations.

Target properties

Protein name	Nuclear factor 1 A-type
UniProt accession	Q12857
Gene	NFIA
Organism	Homo sapiens
Length	509 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (297)

Diseases linked to this target (Open Targets).

chromosome 1p32-p31 deletion syndrome · score 0.71
Nephrosis - deafness - urinary tract - digital malformations · score 0.54
genetic disorder · score 0.51
sex hormone-binding globulin measurement · score 0.42
Myopia · score 0.42
heel bone mineral density · score 0.39
triglyceride measurement · score 0.39
Intellectual disability · score 0.38
cortical thickness · score 0.38
age at onset · score 0.38

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q12857-F1	alphafold	PREDICTED	62.72	—

Amino-acid sequence (509 residues)

MYSPLCLTQD EFHPFIEALL PHVRAFAYTW FNLQARKRKY FKKHEKRMSK EEERAVKDEL LSEKPEVKQK WASRLLAKLR KDIRPEYRED FVLTVTGKKP PCCVLSNPDQ KGKMRRIDCL RQADKVWRLD LVMVILFKGI PLESTDGERL VKSPQCSNPG LCVQPHHIGV SVKELDLYLA YFVHAADSSQ SESPSQPSDA DIKDQPENGH LGFQDSFVTS GVFSVTELVR VSQTPIAAGT GPNFSLSDLE SSSYYSMSPG AMRRSLPSTS STSSTKRLKS VEDEMDSPGE EPFYTGQGRS PGSGSQSSGW HEVEPGMPSP TTLKKSEKSG FSSPSPSQTS SLGTAFTQHH RPVITGPRAS PHATPSTLHF PTSPIIQQPG PYFSHPAIRY HPQETLKEFV QLVCPDAGQQ AGQVGFLNPN GSSQGKVHNP FLPTPMLPPP PPPPMARPVP LPVPDTKPPT TSTEGGAASP TSPTYSTPST SPANRFVSVG PRDPSFVNIP QQTQSWYLG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards