About Contactin-1
Contactin-1 (CNTN1) is a protein
from Homo sapiens identified by UniProt accession
Q12860, 1018 residues long.
MolForge cross-references it against 0 known binders and
289 disease associations.
Target properties
| Protein name | Contactin-1 |
|---|
| UniProt accession | Q12860 |
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| Gene | CNTN1 |
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| Organism | Homo sapiens |
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| Length | 1018 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (289)
Diseases linked to this target (Open Targets).
- Compton-North congenital myopathy · score 0.64
- Congenital lethal myopathy, Compton-North type · score 0.49
- blood protein measurement · score 0.32
- skin pigmentation · score 0.30
- Parkinson disease · score 0.28
- breast adenocarcinoma · score 0.22
- head and neck squamous cell carcinoma · score 0.21
- glioblastoma multiforme · score 0.20
- genetic disorder · score 0.19
- ovarian cancer · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q12860-F1 | alphafold | PREDICTED | 87.24 | — |
Amino-acid sequence (1018 residues)
MKMWLLVSHL VIISITTCLA EFTWYRRYGH GVSEEDKGFG PIFEEQPINT IYPEESLEGK VSLNCRARAS PFPVYKWRMN NGDVDLTSDR YSMVGGNLVI NNPDKQKDAG IYYCLASNNY GMVRSTEATL SFGYLDPFPP EERPEVRVKE GKGMVLLCDP PYHFPDDLSY RWLLNEFPVF ITMDKRRFVS QTNGNLYIAN VEASDKGNYS CFVSSPSITK SVFSKFIPLI PIPERTTKPY PADIVVQFKD VYALMGQNVT LECFALGNPV PDIRWRKVLE PMPSTAEIST SGAVLKIFNI QLEDEGIYEC EAENIRGKDK HQARIYVQAF PEWVEHINDT EVDIGSDLYW PCVATGKPIP TIRWLKNGYA YHKGELRLYD VTFENAGMYQ CIAENTYGAI YANAELKILA LAPTFEMNPM KKKILAAKGG RVIIECKPKA APKPKFSWSK GTEWLVNSSR ILIWEDGSLE INNITRNDGG IYTCFAENNR GKANSTGTLV ITDPTRIILA PINADITVGE NATMQCAASF DPALDLTFVW SFNGYVIDFN KENIHYQRNF MLDSNGELLI RNAQLKHAGR YTCTAQTIVD NSSASADLVV RGPPGPPGGL RIEDIRATSV ALTWSRGSDN HSPISKYTIQ TKTILSDDWK DAKTDPPIIE GNMEAARAVD LIPWMEYEFR VVATNTLGRG EPSIPSNRIK TDGAAPNVAP SDVGGGGGRN RELTITWAPL SREYHYGNNF GYIVAFKPFD GEEWKKVTVT NPDTGRYVHK DETMSPSTAF QVKVKAFNNK GDGPYSLVAV INSAQDAPSE APTEVGVKVL SSSEISVHWE HVLEKIVESY QIRYWAAHDK EEAANRVQVT SQEYSARLEN LLPDTQYFIE VGACNSAGCG PPSDMIEAFT KKAPPSQPPR IISSVRSGSR YIITWDHVVA LSNESTVTGY KVLYRPDGQH DGKLYSTHKH SIEVPIPRDG EYVVEVRAHS DGGDGVVSQV KISGAPTLSP SLLGLLLPAF GILVYLEF
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