Splicing factor 3A subunit 3 (SF3A3)

About Splicing factor 3A subunit 3

Splicing factor 3A subunit 3 (SF3A3) is a protein from Homo sapiens identified by UniProt accession Q12874, 501 residues long. MolForge cross-references it against 0 known binders and 57 disease associations.

Target properties

Protein name	Splicing factor 3A subunit 3
UniProt accession	Q12874
Gene	SF3A3
Organism	Homo sapiens
Length	501 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (57)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.50
heel bone mineral density · score 0.25
lean body mass · score 0.24
appendicular lean mass · score 0.22
coronary artery disease · score 0.21
body height · score 0.20
bone quantitative ultrasound measurement · score 0.19
balding measurement · score 0.19
colorectal cancer · score 0.19
pulse pressure measurement · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q12874-F1	alphafold	PREDICTED	86.23	—

Amino-acid sequence (501 residues)

METILEQQRR YHEEKERLMD VMAKEMLTKK STLRDQINSD HRTRAMQDRY MEVSGNLRDL YDDKDGLRKE ELNAISGPNE FAEFYNRLKQ IKEFHRKHPN EICVPMSVEF EELLKARENP SEEAQNLVEF TDEEGYGRYL DLHDCYLKYI NLKASEKLDY ITYLSIFDQL FDIPKERKNA EYKRYLEMLL EYLQDYTDRV KPLQDQNELF GKIQAEFEKK WENGTFPGWP KETSSALTHA GAHLDLSAFS SWEELASLGL DRLKSALLAL GLKCGGTLEE RAQRLFSTKG KSLESLDTSL FAKNPKSKGT KRDTERNKDI AFLEAQIYEY VEILGEQRHL THENVQRKQA RTGEEREEEE EEQISESESE DEENEIIYNP KNLPLGWDGK PIPYWLYKLH GLNINYNCEI CGNYTYRGPK AFQRHFAEWR HAHGMRCLGI PNTAHFANVT QIEDAVSLWA KLKLQKASER WQPDTEEEYE DSSGNVVNKK TYEDLKRQGL L

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards