About Protoheme IX farnesyltransferase, mitochondrial
Protoheme IX farnesyltransferase, mitochondrial (COX10) is a protein
from Homo sapiens identified by UniProt accession
Q12887, 443 residues long.
MolForge cross-references it against 0 known binders and
80 disease associations.
Target properties
| Protein name | Protoheme IX farnesyltransferase, mitochondrial |
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| UniProt accession | Q12887 |
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| Gene | COX10 |
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| Organism | Homo sapiens |
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| Length | 443 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (80)
Diseases linked to this target (Open Targets).
- mitochondrial complex 4 deficiency, nuclear type 3 · score 0.80
- Leigh syndrome · score 0.59
- neurodegenerative disease · score 0.50
- cytochrome-c oxidase deficiency disease · score 0.46
- leigh syndrome due to mitochondrial complex iv deficiency · score 0.46
- mitochondrial complex IV deficiency, nuclear type 22 · score 0.46
- sex hormone-binding globulin measurement · score 0.38
- mitochondrial disease · score 0.37
- Isolated cytochrome C oxidase deficiency · score 0.37
- serum albumin measurement · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q12887-F1 | alphafold | PREDICTED | 77.43 | — |
Amino-acid sequence (443 residues)
MAASPHTLSS RLLTGCVGGS VWYLERRTIQ DSPHKFLHLL RNVNKQWITF QHFSFLKRMY VTQLNRSHNQ QVRPKPEPVA SPFLEKTSSG QAKAEIYEMR PLSPPSLSLS RKPNEKELIE LEPDSVIEDS IDVGKETKEE KRWKEMKLQV YDLPGILARL SKIKLTALVV STTAAGFALA PGPFDWPCFL LTSVGTGLAS CAANSINQFF EVPFDSNMNR TKNRPLVRGQ ISPLLAVSFA TCCAVPGVAI LTLGVNPLTG ALGLFNIFLY TCCYTPLKRI SIANTWVGAV VGAIPPVMGW TAATGSLDAG AFLLGGILYS WQFPHFNALS WGLREDYSRG GYCMMSVTHP GLCRRVALRH CLALLVLSAA APVLDITTWT FPIMALPINA YISYLGFRFY VDADRRSSRR LFFCSLWHLP LLLLLMLTCK RPSGGGDAGP PPS
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