About Transmembrane protein 115
Transmembrane protein 115 (TMEM115) is a protein
from Homo sapiens identified by UniProt accession
Q12893, 351 residues long.
MolForge cross-references it against 0 known binders and
58 disease associations.
Target properties
| Protein name | Transmembrane protein 115 |
|---|
| UniProt accession | Q12893 |
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| Gene | TMEM115 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 351 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (58)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.50
- breast adenocarcinoma · score 0.10
- Lipedema · score 0.05
- Milroy disease · score 0.05
- platelet count · score 0.05
- high density lipoprotein cholesterol measurement · score 0.05
- normal pressure hydrocephalus · score 0.04
- nephrotic syndrome · score 0.04
- lymphatic malformation 8 · score 0.04
- chronotype measurement · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q12893-F1 | alphafold | PREDICTED | 78.58 | — |
Amino-acid sequence (351 residues)
MQRALPGARQ HLGAILASAS VVVKALCAAV LFLYLLSFAV DTGCLAVTPG YLFPPNFWIW TLATHGLMEQ HVWDVAISLT TVVVAGRLLE PLWGALELLI FFSVVNVSVG LLGAFAYLLT YMASFNLVYL FTVRIHGALG FLGGVLVALK QTMGDCVVLR VPQVRVSVMP MLLLALLLLL RLATLLQSPA LASYGFGLLS SWVYLRFYQR HSRGRGDMAD HFAFATFFPE ILQPVVGLLA NLVHSLLVKV KICQKTVKRY DVGAPSSITI SLPGTDPQDA ERRRQLALKA LNERLKRVED QSIWPSMDDD EEESGAKVDS PLPSDKAPTP PGKGAAPESS LITFEAAPPT L
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