Interferon-related developmental regulator 2 (IFRD2)

About Interferon-related developmental regulator 2

Interferon-related developmental regulator 2 (IFRD2) is a protein from Homo sapiens identified by UniProt accession Q12894, 442 residues long. MolForge cross-references it against 0 known binders and 35 disease associations.

Target properties

Protein name	Interferon-related developmental regulator 2
UniProt accession	Q12894
Gene	IFRD2
Organism	Homo sapiens
Length	442 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (35)

Diseases linked to this target (Open Targets).

reticulocyte count · score 0.65
reticulocyte measurement · score 0.65
Immature Reticulocyte Fraction Measurement · score 0.60
mean reticulocyte volume · score 0.45
basophil count · score 0.09
blood protein measurement · score 0.07
basophil percentage of leukocytes · score 0.07
serum urea measurement · score 0.06
mean corpuscular volume · score 0.05
schizophrenia · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q12894-F1	alphafold	PREDICTED	85.06	—

Amino-acid sequence (442 residues)

MPRARKGNTL RKGGQRRGGG ARSSAQADSG SSDDEAASEA RSTASECPSL LSTTAEDSLG GDVVDEQGQQ EDLEEKLKEY VDCLTDKSAK TRQGALESLR LALASRLLPD FLLERRLTLA DALEKCLKKG KGEEQALAAA VLGLLCVQLG PGPKGEELFH SLQPLLVSVL SDSTASPAAR LHCASALGLG CYVAAADIQD LVSCLACLES VFSRFYGLGG SSTSPVVPAS LHGLLSAALQ AWALLLTICP STQISHILDR QLPRLPQLLS SESVNLRIAA GETIALLFEL ARDLEEEFVY EDMEALCSVL RTLATDSNKY RAKADRRRQR STFRAVLHSV EGGECEEEIV RFGFEVLYMD SWARHRIYAA FKEVLGSGMH HHLQNNELLR DIFGLGPVLL LDATALKACK VPRFEKHLYN AAAFKARTKA RSRVRDKRAD IL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards