About Tripartite motif-containing protein 26
Tripartite motif-containing protein 26 (TRIM26) is a protein
from Homo sapiens identified by UniProt accession
Q12899, 539 residues long.
MolForge cross-references it against 0 known binders and
87 disease associations.
Target properties
| Protein name | Tripartite motif-containing protein 26 |
|---|
| UniProt accession | Q12899 |
|---|
| Gene | TRIM26 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 539 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (87)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.30
- schizophrenia · score 0.27
- autism spectrum disorder · score 0.19
- unipolar depression · score 0.19
- bipolar disorder · score 0.19
- attention deficit hyperactivity disorder · score 0.19
- Non-steroidal anti-inflammatory and antirheumatic product use measurement · score 0.19
- thyroid gland adenocarcinoma · score 0.18
- asthma · score 0.18
- childhood onset asthma · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q12899-F1 | alphafold | PREDICTED | 83.53 | — |
Amino-acid sequence (539 residues)
MATSAPLRSL EEEVTCSICL DYLRDPVTID CGHVFCRSCT TDVRPISGSR PVCPLCKKPF KKENIRPVWQ LASLVENIER LKVDKGRQPG EVTREQQDAK LCERHREKLH YYCEDDGKLL CVMCRESREH RPHTAVLMEK AAQPHREKIL NHLSTLRRDR DKIQGFQAKG EADILAALKK LQDQRQYIVA EFEQGHQFLR EREEHLLEQL AKLEQELTEG REKFKSRGVG ELARLALVIS ELEGKAQQPA AELMQDTRDF LNRYPRKKFW VGKPIARVVK KKTGEFSDKL LSLQRGLREF QGKLLRDLEY KTVSVTLDPQ SASGYLQLSE DWKCVTYTSL YKSAYLHPQQ FDCEPGVLGS KGFTWGKVYW EVEVEREGWS EDEEEGDEEE EGEEEEEEEE AGYGDGYDDW ETDEDEESLG DEEEEEEEEE EEVLESCMVG VARDSVKRKG DLSLRPEDGV WALRLSSSGI WANTSPEAEL FPALRPRRVG IALDYEGGTV TFTNAESQEL IYTFTATFTR RLVPFLWLKW PGTRLLLRP
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