Interleukin enhancer-binding factor 2 (ILF2)

About Interleukin enhancer-binding factor 2

Interleukin enhancer-binding factor 2 (ILF2) is a protein from Homo sapiens identified by UniProt accession Q12905, 390 residues long. MolForge cross-references it against 0 known binders and 82 disease associations.

Target properties

Protein name	Interleukin enhancer-binding factor 2
UniProt accession	Q12905
Gene	ILF2
Organism	Homo sapiens
Length	390 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (82)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
hepatocellular carcinoma · score 0.09
esophageal squamous cell carcinoma · score 0.09
gonorrhea · score 0.09
oral squamous cell carcinoma · score 0.08
Miyoshi myopathy · score 0.08
melanoma · score 0.07
small cell lung carcinoma · score 0.07
metastatic melanoma · score 0.07
pancreatic carcinoma · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q12905-F1	alphafold	PREDICTED	89.63	—

Amino-acid sequence (390 residues)

MRGDRGRGRG GRFGSRGGPG GGFRPFVPHI PFDFYLCEMA FPRVKPAPDE TSFSEALLKR NQDLAPNSAE QASILSLVTK INNVIDNLIV APGTFEVQIE EVRQVGSYKK GTMTTGHNVA DLVVILKILP TLEAVAALGN KVVESLRAQD PSEVLTMLTN ETGFEISSSD ATVKILITTV PPNLRKLDPE LHLDIKVLQS ALAAIRHARW FEENASQSTV KVLIRLLKDL RIRFPGFEPL TPWILDLLGH YAVMNNPTRQ PLALNVAYRR CLQILAAGLF LPGSVGITDP CESGNFRVHT VMTLEQQDMV CYTAQTLVRI LSHGGFRKIL GQEGDASYLA SEISTWDGVI VTPSEKAYEK PPEKKEGEEE EENTEEPPQG EEEESMETQE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards