Vesicular integral-membrane protein VIP36 (LMAN2)

About Vesicular integral-membrane protein VIP36

Vesicular integral-membrane protein VIP36 (LMAN2) is a protein from Homo sapiens identified by UniProt accession Q12907, 356 residues long. MolForge cross-references it against 0 known binders and 78 disease associations.

Target properties

Protein name	Vesicular integral-membrane protein VIP36
UniProt accession	Q12907
Gene	LMAN2
Organism	Homo sapiens
Length	356 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (78)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.25
body weights and measures · score 0.22
reticulocyte count · score 0.21
body height · score 0.20
urate measurement · score 0.16
mean platelet volume · score 0.15
platelet count · score 0.15
leukocyte count · score 0.15
eosinophil percentage of leukocytes · score 0.14
Eczematoid dermatitis · score 0.14

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q12907-F1	alphafold	PREDICTED	84.09	—

Amino-acid sequence (356 residues)

MAAEGWIWRW GWGRRCLGRP GLLGPGPGPT TPLFLLLLLG SVTADITDGN SEHLKREHSL IKPYQGVGSS SMPLWDFQGS TMLTSQYVRL TPDERSKEGS IWNHQPCFLK DWEMHVHFKV HGTGKKNLHG DGIALWYTRD RLVPGPVFGS KDNFHGLAIF LDTYPNDETT ERVFPYISVM VNNGSLSYDH SKDGRWTELA GCTADFRNRD HDTFLAVRYS RGRLTVMTDL EDKNEWKNCI DITGVRLPTG YYFGASAGTG DLSDNHDIIS MKLFQLMVEH TPDEESIDWT KIEPSVNFLK SPKDNVDDPT GNFRSGPLTG WRVFLLLLCA LLGIVVCAVV GAVVFQKRQE RNKRFY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards