Ileal sodium/bile acid cotransporter (SLC10A2)

About Ileal sodium/bile acid cotransporter

Ileal sodium/bile acid cotransporter (SLC10A2) is a protein from Homo sapiens identified by UniProt accession Q12908, 348 residues long. MolForge cross-references it against 0 known binders and 168 disease associations.

Target properties

Protein name	Ileal sodium/bile acid cotransporter
UniProt accession	Q12908
Gene	SLC10A2
Organism	Homo sapiens
Length	348 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (3)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (168)

Diseases linked to this target (Open Targets).

bile acid malabsorption, primary, 1 · score 0.63
primary ovarian insufficiency · score 0.63
Alagille syndrome · score 0.56
Pruritus · score 0.54
Chronic constipation · score 0.51
cholelithiasis · score 0.47
familial intrahepatic cholestasis · score 0.46
gallstones · score 0.39
progressive familial intrahepatic cholestasis · score 0.39
Constipation · score 0.38

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q12908-F1	alphafold	PREDICTED	82.69	—

Amino-acid sequence (348 residues)

MNDPNSCVDN ATVCSGASCV VPESNFNNIL SVVLSTVLTI LLALVMFSMG CNVEIKKFLG HIKRPWGICV GFLCQFGIMP LTGFILSVAF DILPLQAVVV LIIGCCPGGT ASNILAYWVD GDMDLSVSMT TCSTLLALGM MPLCLLIYTK MWVDSGSIVI PYDNIGTSLV SLVVPVSIGM FVNHKWPQKA KIILKIGSIA GAILIVLIAV VGGILYQSAW IIAPKLWIIG TIFPVAGYSL GFLLARIAGL PWYRCRTVAF ETGMQNTQLC STIVQLSFTP EELNVVFTFP LIYSIFQLAF AAIFLGFYVA YKKCHGKNKA EIPESKENGT EPESSFYKAN GGFQPDEK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards